Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (3) : 1659 - 1679. DOI: 10.1016/j.apsb.2025.01.021

ORIGINAL ARTICLE

Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function

Yuheng Jin ^a ,
Xuxin Qi ^b ,
Xiaoli Yu ^a ,
Xirui Cheng ^b ,
Boya Chen ^b ,
Mingfei Wu ^a ,
Jingyu Zhang ^a ,
Hao Yin ^b ,
Yang Lu ^a ,
Yihui Zhou ^b ,
Ao Pang ^a ,
Yushen Lin ^b ,
Li Jiang ^b ,
Qiuqiu Shi ^a ,
Shuangshuang Geng ^a ,
Yubo Zhou ^h ,
Xiaojun Yao ⁱ ,
Linjie Li ^a ,
Haiting Duan ^a ,
Jinxin Che ^a^,^c^,^* ,
Ji Cao ^b^,^d^,^e^,^f^,^g^,^* ,
Qiaojun He ^b^,^d^,^e^,^g^,^* ,
Xiaowu Dong ^a^,^*

Author information +

^aCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

^bInstitute of Pharmacology & Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences and Cancer Center, Zhejiang University, Hangzhou 310058, China

^cHangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou 310058, China

^dInnovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou 310018, China

^eEngineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou 310000, China

^fCenter for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou 310020, China

^gCancer Center, Zhejiang University, Hangzhou 310058, China

^hZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Guangdong 528400, China

ⁱCentre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao 999078, China

^* Corresponding authors.

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Received	Accepted	Published
2024-09-08	2024-12-18
Issue Date
2026-09-17

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