Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (3) : 1571 - 1588. DOI: 10.1016/j.apsb.2025.02.005

ORIGINAL ARTICLE

eIF3a function in immunity and protection against severe sepsis by regulating B cell quantity and function through m⁶A modification

Qianying Ouyang ^a^,^b^,^c^,^d^,^e ,
Jiajia Cui ^a^,^b^,^c^,^d^,^f^,^g ,
Yang Wang ^h ,
Ke Liu ^a^,^b^,^c^,^d ,
Yan Zhan ^a^,^b^,^c^,^d ,
Wei Zhuo ^a^,^b^,^c^,^d^,ⁱ ,
Juan Chen ^h ,
Honghao Zhou ^a^,^b^,^c^,^d ,
Chenhui Luo ^j ,
Jianming Xia ^k ,
Liansheng Wang ^a^,^b^,^c^,^d ,
Chengxian Guo ^l^,^* ,
Jianting Zhang ^m^,^* ,
Zhaoqian Liu ^a^,^b^,^c^,^d^,^* ,
Jiye Yin ^a^,^b^,^c^,^d^,^*

Author information +

^aDepartment of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha 410008, China

^bInstitute of Clinical Pharmacology, Central South University, Changsha 410078, China

^cEngineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Central South University, Changsha 410078, China

^dNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China

^eDepartment of Lymphoma & Hematology, Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China

^fDepartment of Geratic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China

^gDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China

^hDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China

ⁱDepartment of Pharmacy, Hunan Traditional Chinese Medical College, Zhuzhou 412000, China

^jScientific Research Office, Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China

^kDepartment of Cardiac Surgery, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University, Kunming 650102, China

^lCenter of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha 410017, China

^mDepartment of Cell and Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606, USA

^* Corresponding authors.

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Received	Accepted	Published
2024-06-17	2024-11-29
Issue Date
2026-09-17

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