Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (4) : 2134 - 2155. DOI: 10.1016/j.apsb.2025.02.030

ORIGINAL ARTICLE

Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimer's disease

Zhipei Sang ^a^,^b ,
Shuheng Huang ^b ,
Wanying Tan ^c ,
Yujuan Ban ^a ,
Keren Wang ^d ,
Yufan Fan ^e ,
Hongsong Chen ^f ,
Qiyao Zhang ^b ,
Chanchan Liang ^b ,
Jing Mi ^d ,
Yunqi Gao ^f ,
Ya Zhang ^e ,
Wenmin Liu ^d ,
Jianta Wang ^a ,
Wu Dong ^f^,^* ,
Zhenghuai Tan ^g^,^* ,
Lei Tang ^a^,^* ,
Haibin Luo ^b

Author information +

^aState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550004, China

^bKey Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China

^cCenter of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China

^dCollege of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China

^eShanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

^fCollege of Animal Science and Technology Inner Mongolia Minzu University, Tongliao, Inner Mongolia 028000, China

^gInstitute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China

^* Corresponding authors.

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Received	Accepted	Published
2024-08-30	2025-01-03
Issue Date
2026-09-17

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