Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (1) : 278 - 295. DOI: 10.1016/j.apsb.2024.11.017

ORIGINAL ARTICLE

Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells

Han Liu ^a^,^b ,
Yujie Hong ^a ,
Hui Chen ^a ,
Xianggui Wang ^a ,
Jiale Dong ^a ,
Xiaoqian Li ^a ,
Zihan Shi ^a ,
Qian Zhao ^a ,
Longyuan Zhou ^c ,
JiaXin Wang ^d ,
Qiuling Zeng ^a ,
Qinglin Tang ^a ,
Qi Liu ^a ,
Florian Rieder ^e ,
Baili Chen ^c ,
Minhu Chen ^c ,
Rui Wang ^f^,^g ,
Yao Zhang ^d^,^* ,
Ren Mao ^c^,^* ,
Xianxing Jiang ^a^,^*

Author information +

^aGuangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

^bState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou 730000, China

^cDepartment of Gastroenterology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China

^dDepartment of Gastroenterology, Center for Immune-related Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

^eDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA

^fState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

^gSchool of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Lanzhou University, Lanzhou 730000, China

^* Corresponding authors.

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Received	Accepted	Published
2024-04-11	2024-07-26
Issue Date
2026-09-17

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