Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (6) : 3243 - 3258. DOI: 10.1016/j.apsb.2025.04.007

ORIGINAL ARTICLE

A photodynamic nanohybrid system reverses hypoxia and augment anti-primary and metastatic tumor efficacy of immunotherapy

Haitao Yuan ^a ,
Xiaoxian Wang ^b ,
Xin Sun ^a ,
Di Gu ^c^,^d ,
Jinan Guo ^a^,^d ,
Wei Huang ^e ,
Jingbo Ma ^a ,
Chunjin Fu ^a ,
Da Yin ^a^,^* ,
Guohua Zeng ^c^,^d^,^* ,
Ying Long ^b^,^* ,
Jigang Wang ^a^,^c^,^f^,^g^,^* ,
Zhijie Li ^a^,^*

Author information +

^aDepartment of Cardiology, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatric, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China

^bDepartment of Hyperbaric Oxygen Medicine, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China

^cGuangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510230, China

^dDepartment of Urology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China

^eSchool of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, China

^fState Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, China

^gState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

^* Corresponding authors.

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Received	Accepted	Published
2024-10-19	2025-02-20
Issue Date
2026-04-03

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