Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B ›› 2025, Vol. 15 ›› Issue (6) : 3041 - 3058. DOI: 10.1016/j.apsb.2025.04.017

ORIGINAL ARTICLE

SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts

Tongzhu Jin ^a^,^b ,
Huiying Gao ^a ,
Yuquan Wang ^a^,^c ,
Zhiwei Ning ^a ,
Danyang Bing ^a ,
Yan Wang ^a ,
Yi Chen ^a ,
Xiaomu Tian ^a ,
Qiudi Liu ^a ,
Zhihui Niu ^a ,
Jiayu Guo ^a ,
Jian Sun ^d ,
Ruoxuan Yang ^a ,
Qianqian Wang ^a ,
Shifen Li ^a ,
Tianyu Li ^a ,
Yuhong Zhou ^e ,
Wenxin He ^f^,^* ,
Yanjie Lu ^a^,^* ,
Yunyan Gu ^a^,^c^,^* ,
Haihai Liang ^a^,^b^,^g^,^*

Author information +

^aState Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Labratoray-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China

^bDepartment of Nephrology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China

^cDepartment of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China

^dTranslational Medicine Research Center, Medical Pathology Center, Chongqing University Three Gorges Hospital, School of Medicine Chongqing University, Chongqing University, Chongqing 400000, China

^eDepartment of Basic Medicine, Xiamen Medical College, Xiamen 361023, China

^fDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China

^gResearch Unit of Noninfectious Chronic Diseases in Frigid Zone (2019RU070), Chinese Academy of Medical Sciences, Harbin 150081, China

^* Corresponding authors.

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Received	Accepted	Published
2024-12-05	2025-03-03
Issue Date
2026-04-03

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