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Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies
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Liang Liao, Qiang Wang, Zhengyang Gao, Jiayao Liu, Yuxuan Tong, Xin Chen, Jin Zhu, Jian Li, Jinlian Wei
Acta Pharmaceutica Sinica B | 2026, 16(1) : 647 - 650
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Acta Pharmaceutica Sinica B | 2026, 16(1): 647-650
• Letters to the editor •
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies
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Liang Liao, Qiang Wang, Zhengyang Gao, Jiayao Liu, Yuxuan Tong, Xin Chen, Jin Zhu, Jian Li, Jinlian Wei
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doi: 10.1016/j.apsb.2025.10.033
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CRBN  /  Fluorescence polarization  /  Rifamycin O  /  Novel ligand  /  Hematopoietic malignancies  /  IKZF1/3  /  Molecular glue  /  Proteasomal degradation
Liang Liao, Qiang Wang, Zhengyang Gao, Jiayao Liu, Yuxuan Tong, Xin Chen, Jin Zhu, Jian Li, Jinlian Wei. Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies[J]. Acta Pharmaceutica Sinica B, 2026 , 16 (1) : 647 -650 . DOI: 10.1016/j.apsb.2025.10.033
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Year 2026 volume 16 Issue 1
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doi: 10.1016/j.apsb.2025.10.033
  • Receive Date：2025-01-27
  • Online Date：2026-09-17
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  • Received：2025-01-27
  • Revised：2025-07-20
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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