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Non-blocking anti-PD-L1 nanobody conjugated to TLR7 agonist mediates macrophage/NK cell-associated antitumor effects
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Acta Pharmaceutica Sinica B | 2025, 15(7) : 3819 - 3823
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Acta Pharmaceutica Sinica B | 2025, 15(7): 3819-3823
• Letter to the Editor •
Non-blocking anti-PD-L1 nanobody conjugated to TLR7 agonist mediates macrophage/NK cell-associated antitumor effects
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Chao Hu1, Chen Chen1,2, Xiaolu Yu1,2, Zhiying Li1,3, Feng Tang1,2, Qi Sun1,4, Yiru Long1,2, Likun Gong1,2,5
Affiliations
    1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
    2 University of Chinese Academy of Sciences, Beijing 100049, China;
    3 School of Public Health, China Medical University, Shenyang 110122, China;
    4 School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China;
    5 Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China
doi: 10.1016/j.apsb.2025.05.005
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Chao Hu, Chen Chen, Xiaolu Yu, Zhiying Li, Feng Tang, Qi Sun, Yiru Long, Likun Gong. Non-blocking anti-PD-L1 nanobody conjugated to TLR7 agonist mediates macrophage/NK cell-associated antitumor effects[J]. Acta Pharmaceutica Sinica B, 2025 , 15 (7) : 3819 -3823 . DOI: 10.1016/j.apsb.2025.05.005
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doi: 10.1016/j.apsb.2025.05.005
  • Receive Date：2024-11-15
  • Online Date：2026-09-17
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  • Received：2024-11-15
  • Revised：2025-03-13
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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