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Advances in selective targeting of serine hydrolases: A targeted covalent approach against hCES2A mitigates irinotecan toxicity in vivo
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Acta Pharmaceutica Sinica B | 2025, 15(10) : 5491 - 5492
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Acta Pharmaceutica Sinica B | 2025, 15(10): 5491-5492
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Advances in selective targeting of serine hydrolases: A targeted covalent approach against hCES2A mitigates irinotecan toxicity in vivo
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Elena De Vita1
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    1 Centre for Molecular Cell Biology, Department of Biochemistry, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, UK
doi: 10.1016/j.apsb.2025.09.023
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Human carboxylesterase 2 (hCES2A)  /  Structure-based drug design (SBDD)  /  Donepezil derivatives  /  Structure-activity relationship (SAR)
Elena De Vita. Advances in selective targeting of serine hydrolases: A targeted covalent approach against hCES2A mitigates irinotecan toxicity in vivo[J]. Acta Pharmaceutica Sinica B, 2025 , 15 (10) : 5491 -5492 . DOI: 10.1016/j.apsb.2025.09.023
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doi: 10.1016/j.apsb.2025.09.023
  • Online Date：2026-09-17
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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