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Potential oncogenic risks of Keap1-targeting PROTACs: Caution warranted in drug design
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Zhe Zhao, Wen Ma, Jincen Hao, Gaofei Hu, Xinfeng Wang
Acta Pharmaceutica Sinica B | 2026, 16(6) : 3985 - 3987
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Acta Pharmaceutica Sinica B | 2026, 16(6): 3985-3987
• Commentaries •
Potential oncogenic risks of Keap1-targeting PROTACs: Caution warranted in drug design
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Zhe Zhao, Wen Ma, Jincen Hao, Gaofei Hu, Xinfeng Wang
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doi: 10.1016/j.apsb.2026.03.040
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Keap1  /  Nrf2  /  homoPROTAC  /  Redox homeostasis  /  Oncogenesis
Zhe Zhao, Wen Ma, Jincen Hao, Gaofei Hu, Xinfeng Wang. Potential oncogenic risks of Keap1-targeting PROTACs: Caution warranted in drug design[J]. Acta Pharmaceutica Sinica B, 2026 , 16 (6) : 3985 -3987 . DOI: 10.1016/j.apsb.2026.03.040
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Year 2026 volume 16 Issue 6
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doi: 10.1016/j.apsb.2026.03.040
  • Receive Date：2025-11-13
  • Online Date：2026-09-17
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  • Received：2025-11-13
  • Revised：2026-02-25
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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