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Urate transporters: Structural mechanisms and therapeutic opportunities in drug development
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Acta Pharmaceutica Sinica B | 2026, 16(5) : 3243 - 3248
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Acta Pharmaceutica Sinica B | 2026, 16(5): 3243-3248
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Urate transporters: Structural mechanisms and therapeutic opportunities in drug development
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Qian Yang1, Shujing Xu1, Xiaoyu Shi1, Jianxin Pang2, Ting Wu2, Peng Zhan1,3,4
Affiliations
    1 Department of Medicinal Chemistry, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China;
    2 NMPA Key Laboratory for Research and Evaluation of Drug Metabolism &Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China;
    3 State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China;
    4 State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine (Tianjin Institute of Pharmaceutical Research), Tianjin 300301, China
doi: 10.1016/j.apsb.2026.01.037
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Urate  /  Structural biology  /  URAT1  /  OAT1  /  GLUT9
Qian Yang, Shujing Xu, Xiaoyu Shi, Jianxin Pang, Ting Wu, Peng Zhan. Urate transporters: Structural mechanisms and therapeutic opportunities in drug development[J]. Acta Pharmaceutica Sinica B, 2026 , 16 (5) : 3243 -3248 . DOI: 10.1016/j.apsb.2026.01.037
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doi: 10.1016/j.apsb.2026.01.037
  • Receive Date：2025-08-20
  • Online Date：2026-09-17
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  • Received：2025-08-20
  • Revised：2025-10-02
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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