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Distinctive molecular architectures of Gq- and Gi-coupled GLP-1 receptors
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Acta Pharmaceutica Sinica B | 2026, 16(3) : 1779 - 1785
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Acta Pharmaceutica Sinica B | 2026, 16(3): 1779-1785
• Letters to the editor •
Distinctive molecular architectures of Gq- and Gi-coupled GLP-1 receptors
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Qingtong Zhou1,2, Jie Li3, Yao Zhang3, Xiaoqing Cai4,5, Wei Han1, Dehua Yang2,4,5, Ming-Wei Wang1,2,3,6,7
Affiliations
    1 Research Center for Medicinal Structural Biology, National Research Center for Translational Medicine at Shanghai, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
    2 Research Center for Deepsea Bioresources, Sanya 572025, China;
    3 Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China;
    4 The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
    5 The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
    6 Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, School of Pharmacy, Hainan Medical University, Haikou 570228, China;
    7 Department of Chemistry, School of Science, The University of Tokyo, Tokyo 113-0033, Japan
doi: 10.1016/j.apsb.2026.01.023
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GLP-1R  /  G protein coupling  /  Signaling preference  /  Cryo-electron microscopy
Qingtong Zhou, Jie Li, Yao Zhang, Xiaoqing Cai, Wei Han, Dehua Yang, Ming-Wei Wang. Distinctive molecular architectures of Gq- and Gi-coupled GLP-1 receptors[J]. Acta Pharmaceutica Sinica B, 2026 , 16 (3) : 1779 -1785 . DOI: 10.1016/j.apsb.2026.01.023
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doi: 10.1016/j.apsb.2026.01.023
  • Receive Date：2025-12-11
  • Online Date：2026-09-17
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  • Received：2025-12-11
  • Revised：2025-12-22
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表12种不同金属材料的力学参数
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Number of
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Number of
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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