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Single-cell RNA sequencing-guided drug discovery to alleviate radiotherapy-induced esophageal toxicity
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Acta Pharmaceutica Sinica B | 2026, 16(3) : 1769 - 1772
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Acta Pharmaceutica Sinica B | 2026, 16(3): 1769-1772
• Letters to the editor •
Single-cell RNA sequencing-guided drug discovery to alleviate radiotherapy-induced esophageal toxicity
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Wenling Tu1,2,3, Hangfeng Liu1, Hongyu Lin1,2, Jinkang Zhang1,2, Tang Feng4, Zhenyu Ding4, Qing Li4, Yuhong Shi1, Zehua Zhou1, Shuyu Zhang1,5,3
Affiliations
    1 The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu 610051, China;
    2 School of Bioscience and Technology, Chengdu Medical College, Chengdu 610500, China;
    3 NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), Mianyang 621099, China;
    4 Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China;
    5 Laboratory of Radiation Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China
doi: 10.1016/j.apsb.2025.12.038
Outline
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Radiotherapy-induced esophageal toxicity (RIET)  /  Single-cell RNA sequencing (scRNA-Seq)  /  Drug discovery  /  MAPK/NF-κB pathway  /  AP-1 transcription factor complex  /  T-5224  /  Metformin  /  Pleiotrophin (PTN)
Wenling Tu, Hangfeng Liu, Hongyu Lin, Jinkang Zhang, Tang Feng, Zhenyu Ding, Qing Li, Yuhong Shi, Zehua Zhou, Shuyu Zhang. Single-cell RNA sequencing-guided drug discovery to alleviate radiotherapy-induced esophageal toxicity[J]. Acta Pharmaceutica Sinica B, 2026 , 16 (3) : 1769 -1772 . DOI: 10.1016/j.apsb.2025.12.038
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Year 2026 volume 16 Issue 3
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doi: 10.1016/j.apsb.2025.12.038
  • Receive Date：2025-07-29
  • Online Date：2026-09-17
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  • Received：2025-07-29
  • Revised：2025-09-26
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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