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Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies
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Acta Pharmaceutica Sinica B | 2026, 16(1) : 647 - 650
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Acta Pharmaceutica Sinica B | 2026, 16(1): 647-650
• Letters to the editor •
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies
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Liang Liao1,2, Qiang Wang1, Zhengyang Gao1, Jiayao Liu1, Yuxuan Tong1, Xin Chen1, Jin Zhu1, Jian Li1,3,4, Jinlian Wei1
Affiliations
    1 State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;
    2 Department of Technology Transfer, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
    3 Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832003, China;
    4 Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Pharmacy, Hainan University, Haikou 570228, China
doi: 10.1016/j.apsb.2025.10.033
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CRBN  /  Fluorescence polarization  /  Rifamycin O  /  Novel ligand  /  Hematopoietic malignancies  /  IKZF1/3  /  Molecular glue  /  Proteasomal degradation
Liang Liao, Qiang Wang, Zhengyang Gao, Jiayao Liu, Yuxuan Tong, Xin Chen, Jin Zhu, Jian Li, Jinlian Wei. Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies[J]. Acta Pharmaceutica Sinica B, 2026 , 16 (1) : 647 -650 . DOI: 10.1016/j.apsb.2025.10.033
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Year 2026 volume 16 Issue 1
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doi: 10.1016/j.apsb.2025.10.033
  • Receive Date：2025-01-27
  • Online Date：2026-09-17
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  • Received：2025-01-27
  • Revised：2025-07-20
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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