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Elevated SNHG15 empowers keratinocytes hyperproliferation through activation of STAT3/Cyclin D1 axis in psoriasis
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Acta Pharmaceutica Sinica B | 2025, 15(12) : 6430 - 6443
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Acta Pharmaceutica Sinica B | 2025, 15(12): 6430-6443
• Original articles •
Elevated SNHG15 empowers keratinocytes hyperproliferation through activation of STAT3/Cyclin D1 axis in psoriasis
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Published: 2025-12-25 doi: 10.1016/j.apsb.2025.10.010
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Psoriasis is a common inflammatory skin disease with characterization of epidermal hyperplasia and sustained skin inflammation. Long noncoding RNAs (lncRNAs), which contain more than 200 nucleotide-long transcripts, are emerging as the crux of epigenetic regulators in multiple biological processes and diseases. However, how lncRNAs contribute to the etiology of psoriasis remains to be elucidated. For the first time, this study revealed that SNHG15, which was elevated in cytokines-stimulated keratinocytes and psoriasis lesions, promoted keratinocytes hyperproliferation. Mechanistically, SNHG15 fueled epithelial pathology through activation of STAT3/Cyclin D1 axis. Intriguingly, activation of STAT3 enhanced SNHG15 transcription to form a positive feed-back modulatory loop and consequently augmented the skin lesions in psoriasis. Furthermore, knock down the expression of SNHG15 can counteract the IMQ-induced keratinocytes hyperproliferation in vivo. Taken together, our findings uncover that SNHG15 facilitates epidermal hyperplasia via STAT3/Cyclin D1 axis, which might provide a novel therapeutic avenue for psoriasis treatment.
Psoriasis  /  Long noncoding RNAs  /  SNHG15  /  Keratinocytes  /  Cell proliferation  /  STAT3  /  Cyclin D1  /  RNA interference therapy
. Elevated SNHG15 empowers keratinocytes hyperproliferation through activation of STAT3/Cyclin D1 axis in psoriasis. 药学学报（英文版）, 2025 , 15 (12) : 6430 -6443 . DOI: 10.1016/j.apsb.2025.10.010
. Elevated SNHG15 empowers keratinocytes hyperproliferation through activation of STAT3/Cyclin D1 axis in psoriasis[J]. Acta Pharmaceutica Sinica B, 2025 , 15 (12) : 6430 -6443 . DOI: 10.1016/j.apsb.2025.10.010
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Year 2025 volume 15 Issue 12
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doi: 10.1016/j.apsb.2025.10.010
  • Receive Date：2025-02-18
  • Online Date：2026-10-25
  • Published：2025-12-25
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  • Received：2025-02-18
  • Revised：2025-08-14
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https://castjournals.cast.org.cn/joweb/apsb/EN/10.1016/j.apsb.2025.10.010
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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