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Unlocking the potential of targeted protein degradation via nanoparticle-based universal strategy
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Acta Pharmaceutica Sinica B | 2025, 15(11) : 6082 - 6086
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Acta Pharmaceutica Sinica B | 2025, 15(11): 6082-6086
• Highlights •
Unlocking the potential of targeted protein degradation via nanoparticle-based universal strategy
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Ti-Qiang Zhou1, Weilun Sun1, Zhen-Zhen Wei2, Yuhua Weng1,3,4,5, Dongxu Zhao1, Mengjie Zhang1,3,4,5, Yuanyu Huang1,3,4,5
Affiliations
    1 School of Life Science, School of Interdisciplinary Science, Aerospace Center Hospital, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical, Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing 100081, China;
    2 Integrated Chinese and Western Medicine Institute for Children Health and Drug Innovation, Institute of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China;
    3 School of Medical Engineering, School of Interdisciplinary Science, Affiliated Zhuhai People's Hospital, Beijing Institute of Technology, Zhuhai 519088, China;
    4 Advanced Technology Research Institute, Beijing Institute of Technology, Jinan 250100, China;
    5 Zhengzhou Research Institute, Beijing Institute of Technology, Zhengzhou 450040, China
doi: 10.1016/j.apsb.2025.09.016
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Targeted protein degradation  /  Nanoparticles  /  Cellular transport  /  Nanomedicine  /  Nanoparticle-based strategy  /  Proteins of interest  /  PROTAC  /  Lysosomes
Ti-Qiang Zhou, Weilun Sun, Zhen-Zhen Wei, Yuhua Weng, Dongxu Zhao, Mengjie Zhang, Yuanyu Huang. Unlocking the potential of targeted protein degradation via nanoparticle-based universal strategy[J]. Acta Pharmaceutica Sinica B, 2025 , 15 (11) : 6082 -6086 . DOI: 10.1016/j.apsb.2025.09.016
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Year 2025 volume 15 Issue 11
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doi: 10.1016/j.apsb.2025.09.016
  • Receive Date：2025-02-26
  • Online Date：2026-09-17
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  • Received：2025-02-26
  • Revised：2025-05-14
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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