Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets

Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets

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Lei Qiao^a, Xina Dou^a, Xiaofan Song^a, Jiajing Chang^a, Xiaonan Zeng^a, Lixu Zhu^a, Hongbo Yi^b^,^*, Chunlan Xu^a^,^*

Animal Nutrition | 2023, 15(1) : 99 - 113

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Animal Nutrition | 2023, 15(1): 99-113

• Original Research Article •

Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets

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Lei Qiao^a, Xina Dou^a, Xiaofan Song^a, Jiajing Chang^a, Xiaonan Zeng^a, Lixu Zhu^a, Hongbo Yi^b^,^*, Chunlan Xu^a^,^*

Affiliations

^aSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China

^bState Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science of Guangdong Academy of Agricultural Sciences, Guangzhou, Guangdong 510640, China

Published: 2023-12-10 doi: 10.1016/j.aninu.2023.08.003

Outline

Abstract

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Selenium nanoparticles (SeNPs) are proposed as a safer and more effective selenium delivery system than sodium selenite (Na₂SeO₃). Here, we investigated the effects of replacing dietary Na₂SeO₃ with SeNPs synthesized by Lactobacillus casei ATCC 393 on the growth performance and gut health of early-weaned piglets. Seventy-two piglets (Duroc × Landrace × Large Yorkshire) weaned at 21d of age were divided into the control group (basal diet containing 0.3mg Se/kg from Na₂SeO₃) and SeNPs group (basal diet containing 0.3mg Se/kg from SeNPs) during a 14-d feeding period. The results revealed that SeNPs supplementation increased the average daily gain (P = 0.022) and average daily feed intake (P = 0.033), reduced (P = 0.056) the diarrhea incidence, and improved (P = 0.013) the feed conversion ratio compared with Na₂SeO₃. Additionally, SeNPs increased jejunal microvilli height (P = 0.006) and alleviated the intestinal barrier dysfunction by upregulating (P < 0.05) the expression levels of mucin 2 and tight junction proteins, increasing (P < 0.05) Se availability, and maintaining mitochondrial structure and function, thereby improving antioxidant capacity and immunity. Furthermore, metabolomics showed that SeNPs can regulate lipid metabolism and participate in the synthesis, secretion and action of parathyroid hormone, proximal tubule bicarbonate reclamation and tricarboxylic acid cycle. Moreover, SeNPs increased (P < 0.05) the abundance of Holdemanella and the levels of acetate and propionate. Correlation analysis suggested that Holdemanella was closely associated with the regulatory effects of SeNPs on early-weaned piglets through participating in lipid metabolism. Overall, replacing dietary Na₂SeO₃ with biogenic SeNPs could be a potential nutritional intervention strategy to prevent early-weaning syndrome in piglets.

Key words

Selenium nanoparticle / Early-weaned piglet / Gut homeostasis / Gut microbiota / Metabolites

Cite this Article

Lei Qiao, Xina Dou, Xiaofan Song, Jiajing Chang, Xiaonan Zeng, Lixu Zhu, Hongbo Yi, Chunlan Xu. Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets[J]. Animal Nutrition, 2023 , 15 (1) : 99 -113 . DOI: 10.1016/j.aninu.2023.08.003

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Year 2023 volume 15 Issue 1

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Article Info

doi: 10.1016/j.aninu.2023.08.003

Receive Date：2023-03-03
Online Date：2026-02-03
Published：2023-12-10

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History

Received：2023-03-03
Revised：2023-08-10
Accepted：2023-08-11

Affiliations

^aSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China

Corresponding:

^* Corresponding authors. E-mail addresses: yihongbo@gdaas.cn (H. Yi)

clxu@nwpu.edu.cn (C. Xu).

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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