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An emerging role of arecoline on growth performance, intestinal digestion and absorption capacities and intestinal structural integrity of adult grass carp (Ctenopharyngodon idella)
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Na Yaoa, Lin Fenga, b, c, Weidan Jianga, b, c, Pei Wua, b, c, Hongmei Rena, Hequn Shid, Ling Tange, Shuwei Lie, Caimei Wua, Hua Lia, Yang Liua, b, c, *, Xiaoqiu Zhoua, b, c, *
Animal Nutrition | 2023, 15(1) : 173 - 186
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Animal Nutrition | 2023, 15(1): 173-186
• Original Research Article •
An emerging role of arecoline on growth performance, intestinal digestion and absorption capacities and intestinal structural integrity of adult grass carp (Ctenopharyngodon idella)
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Na Yaoa, Lin Fenga, b, c, Weidan Jianga, b, c, Pei Wua, b, c, Hongmei Rena, Hequn Shid, Ling Tange, Shuwei Lie, Caimei Wua, Hua Lia, Yang Liua, b, c, *, Xiaoqiu Zhoua, b, c, *
Affiliations
  • aAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China
  • bFish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China
  • cKey Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Sichuan, 611130, China
  • dGuangzhou Cohoo Biotech Co., Ltd., Guangzhou, 510663, China
  • eAnimal Nutrition Institute, Sichuan Academy of Animal Science, Sichuan Animtech Feed Co. Ltd, Chengdu, 610066, Sichuan, China
Published: 2023-12-10 doi: 10.1016/j.aninu.2023.07.005
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Arecoline is an alkaloid with important pharmacological effects in the plant areca nut, which has been demonstrated to be an agonist of muscarinic receptors (M receptor). This study explored the influences of dietary arecoline on growth performance, intestinal digestion and absorption abilities, antioxidant capacity, and the apical junction complex (AJC) of adult grass carp (Ctenopharyngodon idella). Adult grass carp (608 to 1512g) were fed at 6 graded levels of dietary arecoline (0, 0.5, 1.0, 1.5, 2.0, and 2.5mg/kg diet) for 9 weeks. The results suggested that appropriate dietary supplementation of arecoline (1.0mg/kg) increased growth parameters and intestinal growth in adult grass carp (P < 0.05), enhanced digestion and absorption capacities (P < 0.05), up-regulated muscarinic receptor 3 (M3) mRNA level (P < 0.05), increased the content of neuropeptide fish substance P (P < 0.05), improved antioxidant capacity by activating the Keap1a/Nrf2 signaling pathway (P < 0.05), reduced intestinal mucosal permeability (P < 0.05), and increased mRNA levels of tight junction (TJ) and adherent junction AJ-related proteins in fish by inhibiting the RhoA/ROCK signaling pathway (RhoA/ROCK/MLCK/NMII) (P < 0.05). In addition, the appropriate arecoline supplementation for adult grass carp was determined to be 1.20, 1.21, 1.07, and 1.19mg/kg based on percentage weight gain, lipase activity, serum diamine oxidase, and protein carbonyl, respectively. Overall, to the best of our knowledge, we investigated for the first time the effects and possible mechanisms of dietary arecoline on intestinal digestive and absorptive capacities and structural integrity in fish and evaluated the appropriate level of supplementation.

Arecoline  /  Ctenopharyngodon idella  /  Digestion capacity  /  Absorption capacity  /  Structural integrity  /  Intestine
Na Yao, Lin Feng, Weidan Jiang, Pei Wu, Hongmei Ren, Hequn Shi, Ling Tang, Shuwei Li, Caimei Wu, Hua Li, Yang Liu, Xiaoqiu Zhou. An emerging role of arecoline on growth performance, intestinal digestion and absorption capacities and intestinal structural integrity of adult grass carp (Ctenopharyngodon idella)[J]. Animal Nutrition, 2023 , 15 (1) : 173 -186 . DOI: 10.1016/j.aninu.2023.07.005
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Article Info
doi: 10.1016/j.aninu.2023.07.005
  • Receive Date：2022-12-16
  • Online Date：2026-02-03
  • Published：2023-12-10
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History
  • Received：2022-12-16
  • Revised：2023-07-06
  • Accepted：2023-07-20
Affiliations
    aAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China
    bFish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China
    cKey Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Ministry of Agriculture and Rural Affairs, Key Laboratory of Sichuan Province, Sichuan, 611130, China
    dGuangzhou Cohoo Biotech Co., Ltd., Guangzhou, 510663, China
    eAnimal Nutrition Institute, Sichuan Academy of Animal Science, Sichuan Animtech Feed Co. Ltd, Chengdu, 610066, Sichuan, China

Corresponding:

* Corresponding authors. E-mail addresses: (Y. Liu)
(X. Zhou).
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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