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Glycerol monolaurate improves intestinal morphology and antioxidant status by suppressing inflammatory responses and nuclear factor kappa-B signaling in lipopolysaccharide-exposed chicken embryos
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Linglian Konga, Yuanli Caib, Xue Pana, Chuanpi Xiaoc, Zhigang Songa, *
Animal Nutrition | 2023, 15(1) : 297 - 306
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Animal Nutrition | 2023, 15(1): 297-306
• Original Research Article •
Glycerol monolaurate improves intestinal morphology and antioxidant status by suppressing inflammatory responses and nuclear factor kappa-B signaling in lipopolysaccharide-exposed chicken embryos
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Linglian Konga, Yuanli Caib, Xue Pana, Chuanpi Xiaoc, Zhigang Songa, *
Affiliations
  • aKey Laboratory of Efficient Utilization of Nongrain Feed Resources, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271018, China
  • bCollege of Life Science, Qilu Normal University, Jinan, Shandong 250200, China
  • cPrecision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, University of Liège, Gembloux 5030, Belgium
Published: 2023-12-10 doi: 10.1016/j.aninu.2023.06.014
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Medium-chain fatty acids and their derivatives are natural ingredients that support immunological functions in animals. The effects of glycerol monolaurate (GML) on intestinal innate immunity and associated molecular mechanisms were investigated using a chicken embryo model. Sixty-four Arbor Acres broiler embryos were randomly allocated into four groups. On embryonic day 17.5, the broiler embryos were administered with 9mg of GML, which was followed by a 12-h incubation period and a 12-h challenge with 32μg of lipopolysaccharide (LPS). On embryonic day 18.5, the jejunum and ileum were harvested. Results indicated that GML reversed the LPS-induced decline in villus height and upregulated the expression of mucin 2 (P < 0.05). GML decreased LPS-induced malondialdehyde production and boosted antioxidant enzyme activity (P < 0.05). GML alleviated LPS-stimulated intestinal secretion of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) (P < 0.05). GML also normalized LPS-induced changes in the gene expression of Toll-like receptor 4, nuclear factor kappa-B p65 (NF-κB p65), cyclooxygenase-2, NOD-like receptor protein 3, IL-18, zonula occludens 1, and occludin (P < 0.05). GML enhanced as well the expression of AMP-activated protein kinase α1 and claudin 1 (P < 0.05). In conclusion, GML improved intestinal morphology and antioxidant status by alleviating inflammatory responses and modulating NF-κB signaling in LPS-challenged broiler embryos.

Glycerol monolaurate  /  Innate immunity  /  Lipopolysaccharide  /  Nuclear factor kappa-B  /  Chicken embryo
Linglian Kong, Yuanli Cai, Xue Pan, Chuanpi Xiao, Zhigang Song. Glycerol monolaurate improves intestinal morphology and antioxidant status by suppressing inflammatory responses and nuclear factor kappa-B signaling in lipopolysaccharide-exposed chicken embryos[J]. Animal Nutrition, 2023 , 15 (1) : 297 -306 . DOI: 10.1016/j.aninu.2023.06.014
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Year 2023 volume 15 Issue 1
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Article Info
doi: 10.1016/j.aninu.2023.06.014
  • Receive Date：2023-02-09
  • Online Date：2026-02-03
  • Published：2023-12-10
Article Data
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History
  • Received：2023-02-09
  • Revised：2023-05-15
  • Accepted：2023-06-29
Affiliations
    aKey Laboratory of Efficient Utilization of Nongrain Feed Resources, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong 271018, China
    bCollege of Life Science, Qilu Normal University, Jinan, Shandong 250200, China
    cPrecision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, University of Liège, Gembloux 5030, Belgium

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* Corresponding author. E-mail address: (Z. Song).
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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