Plant-derived squalene supplementation improves growth performance and alleviates acute oxidative stress-induced growth retardation and intestinal damage in piglets

Plant-derived squalene supplementation improves growth performance and alleviates acute oxidative stress-induced growth retardation and intestinal damage in piglets

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Junquan Tian^a^,^b^,^c, Qian Jiang^a^,^c^,^*, Xuetai Bao^a^,^b, Fan Yang^a^,^b, Yuying Li^d, Haihui Sun^e, Kang Yao^a^,^b^,^*, Yulong Yin^a^,^b^,^c

Animal Nutrition | 2023, 15(1) : 386 - 398

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Animal Nutrition | 2023, 15(1): 386-398

• Original Research Article •

Plant-derived squalene supplementation improves growth performance and alleviates acute oxidative stress-induced growth retardation and intestinal damage in piglets

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Junquan Tian^a^,^b^,^c, Qian Jiang^a^,^c^,^*, Xuetai Bao^a^,^b, Fan Yang^a^,^b, Yuying Li^d, Haihui Sun^e, Kang Yao^a^,^b^,^*, Yulong Yin^a^,^b^,^c

Affiliations

^aNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Key Laboratory of Agro-ecological Processes in Subtropical Region, Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China

^bUniversity of Chinese Academy of Sciences, Beijing, 100008, China

^cCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, 410000, China

^dInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, 410205, China

^eYichun Dahaigui Life Science Co., Ltd, Yichun, 336000, China

Published: 2023-12-10 doi: 10.1016/j.aninu.2023.09.001

Outline

Abstract

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Piglets are particularly susceptible to oxidative stress, which causes inferior growth performance and intestinal damage. Squalene (SQ), a natural bioactive substance enriched in shark liver oil, shows excellent antioxidant properties and can currently be obtained at a low cost from deodorizer distillate during the production of plant oil. This study aimed to evaluate the effects of plant-derived SQ supplementation on the growth performance of piglets and explore the beneficial roles of SQ against oxidative stress and intestinal injury in diquat-challenged piglets. Forty piglets were randomly divided into five groups and fed a basal diet supplemented with SQ at 0, 500, 1000, or 2000mg/kg for 5 weeks. Acute oxidative stress was induced in the piglets with diquat (10mg/kg BW) at the fourth week of the experiment, followed by a 7-d recovery period. Results showed that before the diquat challenge, SQ supplementation significantly improved growth performance (average daily gain and feed conversion ratio) and serum antioxidant status, and after the diquat challenge, SQ supplementation significantly mitigated diquat-induced growth arrest, intestinal villous atrophy, intestinal epithelial cell apoptosis, intestinal hyperpermeability, and deficiency of intestinal epithelial tight junction proteins (zonula occludens-1, occludin, and claudin-3). Under oxidative stress induced by diquat, SQ supplementation consistently improved the antioxidant status of the small intestine, liver, and muscle. In vitro, SQ was shown to alleviate hydrogen peroxide (H₂O₂)-induced increase of the levels of intracellular reactive oxygen species and apoptosis of porcine intestinal epithelial cells. Taken together, SQ supplementation improves growth performance and effectively alleviates acute oxidative stress-induced growth retardation and intestinal injury via improving antioxidant capacity in piglets. Our findings may provide an efficient strategy for alleviating oxidative stress-induced inferior growth performance and intestinal damage in piglets.

Key words

Squalene / Growth performance / Oxidative stress / Intestinal injury / Antioxidant / Piglet

Cite this Article

Junquan Tian, Qian Jiang, Xuetai Bao, Fan Yang, Yuying Li, Haihui Sun, Kang Yao, Yulong Yin. Plant-derived squalene supplementation improves growth performance and alleviates acute oxidative stress-induced growth retardation and intestinal damage in piglets[J]. Animal Nutrition, 2023 , 15 (1) : 386 -398 . DOI: 10.1016/j.aninu.2023.09.001

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Year 2023 volume 15 Issue 1

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Article Info

doi: 10.1016/j.aninu.2023.09.001

Receive Date：2023-05-11
Online Date：2026-02-03
Published：2023-12-10

Article Data

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History

Received：2023-05-11
Revised：2023-09-22
Accepted：2023-09-27

Affiliations

^bUniversity of Chinese Academy of Sciences, Beijing, 100008, China

^cCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, 410000, China

^dInstitute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, 410205, China

^eYichun Dahaigui Life Science Co., Ltd, Yichun, 336000, China

Corresponding:

^* Corresponding authors. E-mail addresses: jiangqian@hunau.edu.cn (Q. Jiang)

yaokang@isa.ac.cn (K. Yao).

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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