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New insights into the unfolded protein response (UPR)-anterior gradient 2 (AGR2) pathway in the regulation of intestinal barrier function in weaned piglets
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Feng Zhanga, b, *, Mengxian Chena, Xiaodan Liua, Xu Jic, Shenghe Lia, b, Erhui Jina, b, *
Animal Nutrition | 2023, 15(1) : 225 - 232
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Animal Nutrition | 2023, 15(1): 225-232
• Review Article •
New insights into the unfolded protein response (UPR)-anterior gradient 2 (AGR2) pathway in the regulation of intestinal barrier function in weaned piglets
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Feng Zhanga, b, *, Mengxian Chena, Xiaodan Liua, Xu Jic, Shenghe Lia, b, Erhui Jina, b, *
Affiliations
  • aCollege of Animal Science, Anhui Science and Technology University, Chuzhou, China
  • bAnhui Province Key Laboratory of Animal Nutrition Regulation and Health, Chuzhou, China
  • cAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Science and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei, China
Published: 2023-12-10 doi: 10.1016/j.aninu.2023.08.007
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Sustained dysfunction of the intestinal barrier caused by early weaning is a major factor that induces postweaning diarrhea in weaned piglets. In both healthy and diseased states, the intestinal barrier is regulated by goblet cells. Alterations in the characteristics of goblet cells are linked to intestinal barrier dysfunction and inflammatory conditions during pathogenic infections. In this review, we summarize the current understanding of the mechanisms of the unfolded protein response (UPR) and anterior gradient 2 (AGR2) in maintaining intestinal barrier function and how modifications to these systems affect mucus barrier characteristics and goblet cell dysregulation. We highlight a novel mechanism underlying the UPR-AGR2 pathway, which affects goblet cell differentiation and maturation and the synthesis and secretion of mucin by regulating epidermal growth factor receptor and mucin 2. This study provides a theoretical basis and new insights into the regulation of intestinal health in weaned piglets.

Weaned piglet  /  Endoplasmic reticulum stress  /  Unfolded protein response  /  Anterior gradient 2  /  Intestinal barrier function
Feng Zhang, Mengxian Chen, Xiaodan Liu, Xu Ji, Shenghe Li, Erhui Jin. New insights into the unfolded protein response (UPR)-anterior gradient 2 (AGR2) pathway in the regulation of intestinal barrier function in weaned piglets[J]. Animal Nutrition, 2023 , 15 (1) : 225 -232 . DOI: 10.1016/j.aninu.2023.08.007
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Article Info
doi: 10.1016/j.aninu.2023.08.007
  • Receive Date：2022-12-08
  • Online Date：2026-02-03
  • Published：2023-12-10
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History
  • Received：2022-12-08
  • Revised：2023-07-05
  • Accepted：2023-08-11
Affiliations
    aCollege of Animal Science, Anhui Science and Technology University, Chuzhou, China
    bAnhui Province Key Laboratory of Animal Nutrition Regulation and Health, Chuzhou, China
    cAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Science and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei, China

Corresponding:

* Corresponding authors. E-mail addresses: (F. Zhang)
(E. Jin).
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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