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Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets
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Yuying Wua, b, Bei Chengb, Longxiang Jic, Xiangyun Lvc, Yingying Fengb, *, Liu’an Lia, *, Xin Wub
Animal Nutrition | 2023, 14(1) : 249 - 258
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Animal Nutrition | 2023, 14(1): 249-258
• Original Research Article •
Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets
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Yuying Wua, b, Bei Chengb, Longxiang Jic, Xiangyun Lvc, Yingying Fengb, *, Liu’an Lia, *, Xin Wub
Affiliations
  • aTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300384, China
  • bTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China
  • cZhumadian Huazhong Chia Tai Co., Ltd., Zhumadian, 463000, China
Published: 2023-09-10 doi: 10.1016/j.aninu.2023.06.003
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Lysozyme (LZ) is a purely natural, nonpolluting and nonspecific immune factor, which has beneficial effects on the healthy development of animals. In this study, the influences of LZ on the growth performance and intestinal barrier of weaned piglets were studied. A total of 48 weaned piglets (Landrace × Yorkshire, 22 d old) were randomly divided into a control group (basal diet) and a LZ group (0.1% LZ diet) for 19 d. The results showed that LZ could significantly improve the average daily gain (ADG, P < 0.05) and average daily feed intake (ADFI, P < 0.05). LZ also improved the intestinal morphology and significantly increased the expression of occludin in the jejunum (P < 0.05). In addition, LZ down-regulated the expression of interleukin-1β (IL-1β, P < 0.05) and tumor necrosis factor-a (TNF-α, P < 0.05), and inhibited the expression of the genes in the nuclear factor-k-gene binding (NF-κB, P<0.05) signaling pathway. More importantly, the analysis of intestinal flora showed LZ increased the abundance of Firmicutes (P < 0.05) and the ratio of Firmicutes to Bacteroidota (P = 0.09) at the phylum level, and increased the abundance of Clostridium_sensu_stricto_1 (P < 0.05) and reduced the abundance of Olsenella and Prevotella (P < 0.05) at the genus level. In short, this study proved that LZ could effectively improve the growth performance, relieve inflammation and improve the intestinal barrier function of weaned piglets. These findings provided an important theoretical basis for the application of LZ in pig production.

Lysozyme  /  Growth performance  /  Intestinal barrier  /  Intestinal flora  /  Weaned piglet
Yuying Wu, Bei Cheng, Longxiang Ji, Xiangyun Lv, Yingying Feng, Liu’an Li, Xin Wu. Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets[J]. Animal Nutrition, 2023 , 14 (1) : 249 -258 . DOI: 10.1016/j.aninu.2023.06.003
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Year 2023 volume 14 Issue 1
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Article Info
doi: 10.1016/j.aninu.2023.06.003
  • Receive Date：2022-10-30
  • Online Date：2026-02-03
  • Published：2023-09-10
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History
  • Received：2022-10-30
  • Revised：2023-05-31
  • Accepted：2023-06-15
Affiliations
    aTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, 300384, China
    bTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China
    cZhumadian Huazhong Chia Tai Co., Ltd., Zhumadian, 463000, China

Corresponding:

* Corresponding authors. E-mail addresses: (Y. Feng)
(L. Li).
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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