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Uridine alleviates high-carbohydrate diet-induced metabolic syndromes by activating sirt1/AMPK signaling pathway and promoting glycogen synthesis in Nile tilapia (Oreochromis niloticus)
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Nan-Nan Zhou, Tong Wang, Yu-Xin Lin, Rong Xu, Hong-Xia Wu, Fei-Fei Ding, Fang Qiao, Zhen-Yu Du, Mei-Ling Zhang*
Animal Nutrition | 2023, 14(1) : 56 - 66
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Animal Nutrition | 2023, 14(1): 56-66
• Original Research Article •
Uridine alleviates high-carbohydrate diet-induced metabolic syndromes by activating sirt1/AMPK signaling pathway and promoting glycogen synthesis in Nile tilapia (Oreochromis niloticus)
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Nan-Nan Zhou, Tong Wang, Yu-Xin Lin, Rong Xu, Hong-Xia Wu, Fei-Fei Ding, Fang Qiao, Zhen-Yu Du, Mei-Ling Zhang*
Affiliations
  • Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai 200241, China
Published: 2023-09-10 doi: 10.1016/j.aninu.2023.03.010
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Carbohydrates have a protein sparing effect, but long-term feeding of a high-carbohydrate diet (HCD) leads to metabolic disorders due to the limited utilization efficiency of carbohydrates in fish. How to mitigate the negative effects induced by HCD is crucial for the rapid development of aquaculture. Uridine is a pyrimidine nucleoside that plays a vital role in regulating lipid and glucose metabolism, but whether uridine can alleviate metabolic syndromes induced by HCD remains unknown. In this study, a total of 480 Nile tilapia (Oreochromis niloticus) (average initial weight 5.02 ± 0.03g) were fed with 4 diets, including a control diet (CON), HCD, HCD + 500 mg/kg uridine (HCUL) and HCD + 5,000 mg/kg uridine (HCUH), for 8 weeks. The results showed that addition of uridine decreased hepatic lipid, serum glucose, triglyceride and cholesterol (P < 0.05). Further analysis indicated that higher concentration of uridine activated the sirtuin1 (sirt1)/adenosine 5-monophosphate-activated protein kinase (AMPK) signaling pathway to increase lipid catabolism and glycolysis while decreasing lipogenesis (P < 0.05). Besides, uridine increased the activity of glycogen synthesis-related enzymes (P < 0.05). This study suggested that uridine could alleviate HCD-induced metabolic syndrome by activating the sirt1/AMPK signaling pathway and promoting glycogen synthesis. This finding reveals the function of uridine in fish metabolism and facilitates the development of new additives in aquatic feeds.

Uridine  /  High-carbohydrate  /  diet Metabolism  /  AMPK  /  Nile tilapia
Nan-Nan Zhou, Tong Wang, Yu-Xin Lin, Rong Xu, Hong-Xia Wu, Fei-Fei Ding, Fang Qiao, Zhen-Yu Du, Mei-Ling Zhang. Uridine alleviates high-carbohydrate diet-induced metabolic syndromes by activating sirt1/AMPK signaling pathway and promoting glycogen synthesis in Nile tilapia (Oreochromis niloticus)[J]. Animal Nutrition, 2023 , 14 (1) : 56 -66 . DOI: 10.1016/j.aninu.2023.03.010
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Year 2023 volume 14 Issue 1
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Article Info
doi: 10.1016/j.aninu.2023.03.010
  • Receive Date：2022-10-28
  • Online Date：2026-02-03
  • Published：2023-09-10
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History
  • Received：2022-10-28
  • Revised：2023-01-06
  • Accepted：2023-03-21
Affiliations
    Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai 200241, China

Corresponding:

* Corresponding author. E-mail address: (M.-L. Zhang).
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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