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Sodium butyrate promotes gastrointestinal development of preweaning bull calves via inhibiting inflammation, balancing nutrient metabolism, and optimizing microbial community functions
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Huiyue Zhonga, Wenjing Yub, Min Wangc, Bo Linb, Xuezhao Sund, e, Nan Zhenga, Jiaqi Wanga, *, Shengguo Zhaoa, *
Animal Nutrition | 2023, 14(1) : 88 - 100
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Animal Nutrition | 2023, 14(1): 88-100
• Original Research Article •
Sodium butyrate promotes gastrointestinal development of preweaning bull calves via inhibiting inflammation, balancing nutrient metabolism, and optimizing microbial community functions
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Huiyue Zhonga, Wenjing Yub, Min Wangc, Bo Linb, Xuezhao Sund, e, Nan Zhenga, Jiaqi Wanga, *, Shengguo Zhaoa, *
Affiliations
  • aState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
  • bDepartment of Animal Science and Technology, Guangxi University, Nanning, 530005, China
  • cInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China
  • dJilin Inter-regional Cooperation Centre for the Scientific and Technological Innovation of Ruminant Precision Nutrition and Smart and Ecological Farming, Jilin Agricultural Science and Technology University, Jilin, 132109, China
  • eGrasslands Research Centre, AgResearch Limited, Palmerston North, New Zealand
Published: 2023-09-10 doi: 10.1016/j.aninu.2023.04.004
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Butyrate promotes the growth and gastrointestinal development of calves. But, the mechanisms behind its effects on signaling pathways of the gastrointestinal tract and rumen microbiome is unclear. This study aimed to reveal transcriptomic pathways of gastrointestinal epithelium and microbial community in response to butyrate supplementation in calves fed a high fiber starter. Fourteen Holstein bull calves (39.9 ± 3.7 kg, 14 d of age) were assigned to 2 groups (sodium butyrate group, SB; control group, Ctrl). The SB group received 0.5% SB supplementation. At d 51, the calves were slaughtered to obtain samples for analysis of the transcriptome of the rumen and jejunum epithelium as well as ruminal microbial metagenome. Sodium butyrate supplementation resulted in a higher performance in average daily gain and development of jejunum and rumen papillae. In both the rumen and jejunum epithelium, SB down-regulated pathways related to inflammation including NF-κB (PPKCB, CXCL8, CXCL12), interleukin-17 (IL17A, IL17B, MMP9), and chemokine (CXCL12, CCL4, CCL8) and up-regulated immune pathways including the intestinal immune network for immunoglobulin A (IgA) production (CD28). Meanwhile, in the jejunum epithelium, SB regulated pathways related to nutritional metabolism including nitrogen metabolism (CA1, CA2, CA3), synthesis and degradation of ketone bodies (HMGCS2, BDH1, LOC100295719), fat digestion and absorption (PLA2G2F, APOA1, APOA4), and the PPAR signaling pathway (FABP4, FABP6, CYP4A11). The metagenome showed that SB greatly increased the relative abundance of Bacillus subtilis and Eubacterium limosum, activated ruminal microbial carbohydrate metabolism pathways and increased the abundance of carbohydrate hydrolysis enzymes. In conclusion, butyrate exhibited promoting effects on growth and gastrointestinal development by inhibiting inflammation, enhancing immunity and energy harvesting, and activating microbial carbohydrate metabolism. These findings provide new insights into the potential mechanisms behind the beneficial effects of butyrate in calf nutrition.

Sodium butyrate  /  Calf  /  Gastrointestinal development  /  Inflammation  /  Transcriptomics  /  Microbiome
Huiyue Zhong, Wenjing Yu, Min Wang, Bo Lin, Xuezhao Sun, Nan Zheng, Jiaqi Wang, Shengguo Zhao. Sodium butyrate promotes gastrointestinal development of preweaning bull calves via inhibiting inflammation, balancing nutrient metabolism, and optimizing microbial community functions[J]. Animal Nutrition, 2023 , 14 (1) : 88 -100 . DOI: 10.1016/j.aninu.2023.04.004
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Year 2023 volume 14 Issue 1
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Article Info
doi: 10.1016/j.aninu.2023.04.004
  • Receive Date：2022-07-09
  • Online Date：2026-02-03
  • Published：2023-09-10
Article Data
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History
  • Received：2022-07-09
  • Revised：2023-03-26
  • Accepted：2023-04-19
Affiliations
    aState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
    bDepartment of Animal Science and Technology, Guangxi University, Nanning, 530005, China
    cInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China
    dJilin Inter-regional Cooperation Centre for the Scientific and Technological Innovation of Ruminant Precision Nutrition and Smart and Ecological Farming, Jilin Agricultural Science and Technology University, Jilin, 132109, China
    eGrasslands Research Centre, AgResearch Limited, Palmerston North, New Zealand

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* Corresponding authors. E-mail addresses: (J. Wang)
(S. Zhao).
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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