Dietary adenosine supplementation improves placental angiogenesis in IUGR piglets by up-regulating adenosine A2a receptor

Dietary adenosine supplementation improves placental angiogenesis in IUGR piglets by up-regulating adenosine A2a receptor

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Zifang Wu^a^,¹, Jiawei Nie^a^,¹, Deyuan Wu^a, Shuangbo Huang^a, Jianzhao Chen^a, Huajin Liang^a, Xiangyu Hao^a, Li Feng^a, Hefeng Luo^b^,^*, Chengquan Tan^a^,^*

Animal Nutrition | 2023, 13(1) : 282 - 288

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Animal Nutrition | 2023, 13(1): 282-288

• Original Research Article •

Dietary adenosine supplementation improves placental angiogenesis in IUGR piglets by up-regulating adenosine A2a receptor

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Zifang Wu^a^,¹, Jiawei Nie^a^,¹, Deyuan Wu^a, Shuangbo Huang^a, Jianzhao Chen^a, Huajin Liang^a, Xiangyu Hao^a, Li Feng^a, Hefeng Luo^b^,^*, Chengquan Tan^a^,^*

Affiliations

^aGuangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China

^bDekon Food and Agriculture Group, Chengdu, China

Published: 2023-06-10 doi: 10.1016/j.aninu.2023.02.003

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Abstract

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Abnormal placental angiogenesis is associated with the occurrence of intrauterine growth restriction (IUGR) in piglets, and effective treatment strategies against this occurrence remain to be explored. Adenosine has been reported to play an important role in angiogenesis, but its role in placental angiogenesis is still unknown. Here, we investigated the effect of dietary adenosine supplementation on IUGR occurrence in piglets by analyzing the role of adenosine in placental angiogenesis for Normal and IUGR piglets. Specifically, 88 sows were allotted to 2 treatments (n = 44) and fed a basal diet supplemented with 0% or 0.1% of adenosine from day 65 of gestation until farrowing, followed by collecting the placental samples of Normal and IUGR piglets, and recording their characteristics. The results showed that adenosine supplementation increased the mean birth weight of piglets (P < 0.05) and placental efficiency (P < 0.05), while decreasing the IUGR piglet rate (P < 0.05). Expectedly, the placenta for IUGR neonates showed a down-regulated vascular density (P < 0.05) and angiogenesis as evidenced by the expression level of vascular cell adhesion molecule-1 (VCAM1) (P < 0.05). Notably, dietary adenosine supplementation promoted angiogenesis (P < 0.05) both in the Normal and IUGR placenta. More importantly, the expression level of adenosine A2a receptor (ADORA2A) was lower (P < 0.05) in the IUGR placenta than in Normal placenta, whereas adenosine treatment could significantly increase ADORA2A expression, and also had an interaction effect between factors IUGR and Ado. Collectively, placentae for IUGR piglets showed impaired angiogenesis and down-regulated expression level of ADORA2A, while dietary adenosine supplementation could activate ADORA2A expression, improve the placental angiogenesis, and ultimately decrease the occurrence of IUGR in piglets.

Key words

Angiogenesis / IUGR / Placenta / Adenosine / ADORA2A

Cite this Article

Zifang Wu, Jiawei Nie, Deyuan Wu, Shuangbo Huang, Jianzhao Chen, Huajin Liang, Xiangyu Hao, Li Feng, Hefeng Luo, Chengquan Tan. Dietary adenosine supplementation improves placental angiogenesis in IUGR piglets by up-regulating adenosine A2a receptor[J]. Animal Nutrition, 2023 , 13 (1) : 282 -288 . DOI: 10.1016/j.aninu.2023.02.003

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Year 2023 volume 13 Issue 1

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Article Info

doi: 10.1016/j.aninu.2023.02.003

Receive Date：2022-04-28
Online Date：2026-02-03
Published：2023-06-10

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History

Received：2022-04-28
Revised：2022-12-09
Accepted：2023-02-15

Affiliations

^bDekon Food and Agriculture Group, Chengdu, China

Corresponding:

^* Corresponding authors. E-mail addresses: sixfires@126.com (H. Luo)

tanchengquan@scau.edu.cn (C. Tan).

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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