Dietary coated essential oil and organic acid mixture supplementation improves health of broilers infected with avian pathogenic <i>Escherichia coli</i>

Dietary coated essential oil and organic acid mixture supplementation improves health of broilers infected with avian pathogenic Escherichia coli

PDF

Van Hieu Pham^a^,^b, Waseem Abbas^a, Jinyu Huang^c, Fangshen Guo^a, Kaichen Zhang^d, Linhua Kong^d, Wenrui Zhen^a, Yuming Guo^a, Zhong Wang^a^,^*

Animal Nutrition | 2023, 12(1) : 245 - 262

Less

Animal Nutrition | 2023, 12(1): 245-262

• Original Research Article •

Dietary coated essential oil and organic acid mixture supplementation improves health of broilers infected with avian pathogenic Escherichia coli

Full

Van Hieu Pham^a^,^b, Waseem Abbas^a, Jinyu Huang^c, Fangshen Guo^a, Kaichen Zhang^d, Linhua Kong^d, Wenrui Zhen^a, Yuming Guo^a, Zhong Wang^a^,^*

Affiliations

^aState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China

^bFaculty of Animal Science and Veterinary Medicine, Thai Nguyen University Agriculture and Forestry, Thai Nguyen, Viet Nam

^cMenon Animal Nutrition Technology Co. Ltd., Shanghai, 201807, China

^dTengzhou Heyi Food Co. Ltd., Zaozhuang, 277000, China

Published: 2023-03-10 doi: 10.1016/j.aninu.2022.09.010

Outline

Abstract

Less

Colibacillosis caused by avian pathogenic Escherichia coli (APEC) is a very prevalent disease in poultry farms in China. The exploration of effective non-antibiotic substances is of great significance for the control of APEC infections. This experiment evaluated the efficacy of coated essential oil and organic acid (EOA) supplementation to prevent E. coli O78 infection in _broiler chickens. A total of 288 one-day-old male broiler chicks were randomly distributed into 4 groups with 6 replicates per group. Chickens were fed a diet either supplemented with EOA (500 mg/kg feed) or not, and either uninfected or infected with E. coli O78 intratracheally. Results showed that E. coli O78 infection reduced body weight gain, increased mortality and the ratio of feed to gain along with cecal and liver E. coli load, damaged gut mucosa, induced local and systemic inflammation, and altered cecal microbial composition, diversity and function (P < 0.05). Supplemental EOA improved feed conversion efficiency, lowered gross lesion scores and cecal E. coli population, enhanced intestinal goblet cells and serum IgG concentration, and tended to decrease serum IL-12 production (P < 0.05). Essential oil and organic acid addition downregulated IFN-γ mRNA, tended to decrease mucin-2 mRNA levels while upregulating IL-10 mRNA, and tended to increase ZO-1 gene expression in the jejuna of infected birds at 7 d after E. coli O78 challenge (P < 0.05). The 16S rRNA gene sequencing indicated that both EOA addition and E. coli O78 challenge altered the diversity and composition of the cecal microbiota community. Furthermore, infected birds fed EOA showed decreased Bacteroidetes and genus Lactobacillus abundance compared with the infected control. LEfSe analysis showed that Firmicutes, Ruminococcaceae, Clostridiales, Clostridia, Lactobacillus, Lactobacilaceae, and cc-115 were enriched in the non-infected but EOA-treated group (P < 0.05). Collectively, dietary EOA supplementation could mildly alleviate E. coli-induced gut injury and inflammation.

Key words

Encapsulated essential oil and organic acid mixture / Avian pathogenic Escherichia coli / Health / Broiler chicken

Cite this Article

Van Hieu Pham, Waseem Abbas, Jinyu Huang, Fangshen Guo, Kaichen Zhang, Linhua Kong, Wenrui Zhen, Yuming Guo, Zhong Wang. Dietary coated essential oil and organic acid mixture supplementation improves health of broilers infected with avian pathogenic Escherichia coli[J]. Animal Nutrition, 2023 , 12 (1) : 245 -262 . DOI: 10.1016/j.aninu.2022.09.010

Full Text

Less

Appendix

Less

Year 2023 volume 12 Issue 1

PDF

Cite this Article

BibTeX

Article Info

doi: 10.1016/j.aninu.2022.09.010

Receive Date：2022-02-18
Online Date：2026-02-03
Published：2023-03-10

Article Data

Affiliations

History

Received：2022-02-18
Revised：2022-09-26
Accepted：2022-09-28

Affiliations

^aState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China

^bFaculty of Animal Science and Veterinary Medicine, Thai Nguyen University Agriculture and Forestry, Thai Nguyen, Viet Nam

^cMenon Animal Nutrition Technology Co. Ltd., Shanghai, 201807, China

^dTengzhou Heyi Food Co. Ltd., Zaozhuang, 277000, China

Corresponding:

^* Corresponding author. E-mail address: wangzh@cau.edu.cn (Z. Wang).

References

Share

https://castjournals.cast.org.cn/joweb/aninu/EN/10.1016/j.aninu.2022.09.010

Share to

Scan QR to access full text

Cite this article

BibTeX

Citations

表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT

Articles: Latest Articles; Most Read; Collections

Updates: Events; News; Multimedia

About: About Us

Contact

No. 86 Xueyuan South Road, Haidian District, Beijing

100081

010-62199257

qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House