Dietary folic acid addition reduces abdominal fat deposition mediated by alterations in gut microbiota and SCFA production in broilers

Dietary folic acid addition reduces abdominal fat deposition mediated by alterations in gut microbiota and SCFA production in broilers

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Yanli Liu^a, Jiantao Yang^a, Xiaoying Liu^a, Rui Liu^a, Yibin Wang^a, Xinhuo Huang^b, Yingge Li^c, Ruifang Liu^a, Xiaojun Yang^a^,^*

Animal Nutrition | 2023, 12(1) : 54 - 62

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Animal Nutrition | 2023, 12(1): 54-62

• Original Research Article •

Dietary folic acid addition reduces abdominal fat deposition mediated by alterations in gut microbiota and SCFA production in broilers

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Yanli Liu^a, Jiantao Yang^a, Xiaoying Liu^a, Rui Liu^a, Yibin Wang^a, Xinhuo Huang^b, Yingge Li^c, Ruifang Liu^a, Xiaojun Yang^a^,^*

Affiliations

^aCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

^bNano Vitamin Engineering Research Center of Shaanxi Province, Xi'an 710000, China

^cShaanxi Province Animal Husbandry Technology Extension Station, Xi'an 710016, China

Published: 2023-03-10 doi: 10.1016/j.aninu.2022.08.013

Outline

Abstract

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Intensive selective breeding for high growth rate and body weight cause excess abdominal fat in broilers. Gut microbiota and folic acid were reported to regulate lipid metabolism. A total of 210 one-day-old broilers were divided into the control (folic acid at 1.3 mg/kg) and folic acid groups (folic acid at 13 mg/kg) to illustrate the effects of folic acid on growth performance, abdominal fat deposition, and gut microbiota, and the experiment lasted 28 d. Results revealed that dietary folic acid addition decreased abdominal fat percentage (P < 0.05) and down-regulated genes expression related to cell proliferation and differentiation in abdominal fat including IGF1, EGF, C/EBPα, PPARγ, PLIN1, FABP4 and PCNA (P < 0.05). Folic acid addition decreased caecal Firmicutes-to-Bacteroidetes ratio (P < 0.01) and increased the proportions of Alistipes, Oscillospira, Ruminococcus, Clostridium, Dehalobacterium and Parabacteroides (P < 0.05). Caecal acetic acid, and propionic acid contents were found to be higher under folic acid treatment (P < 0.05), which were negatively related to genes expression associated with adipocyte proliferation and differentiation (P < 0.05). Ruminococcus was positively correlated with caecal acetic acid content, and the same phenomenon was detected between propionic acid and Oscillospira and Ruminococcus (P < 0.05). Acetic acid and Oscillospira were identified to be negatively associated with abdominal fat percentage (P < 0.05). In conclusion, our data demonstrated that dietary supplementation of folic acid reduced fat deposition in broilers by inhibiting abdominal adipocyte proliferation and differentiation, which might be mediated by changes in gut microbiota and short chain fatty acid production.

Key words

Folic acid / Caecal microbiota / Abdominal adipocytes / Short chain fatty acid / Broilers

Cite this Article

Yanli Liu, Jiantao Yang, Xiaoying Liu, Rui Liu, Yibin Wang, Xinhuo Huang, Yingge Li, Ruifang Liu, Xiaojun Yang. Dietary folic acid addition reduces abdominal fat deposition mediated by alterations in gut microbiota and SCFA production in broilers[J]. Animal Nutrition, 2023 , 12 (1) : 54 -62 . DOI: 10.1016/j.aninu.2022.08.013

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Year 2023 volume 12 Issue 1

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Article Info

doi: 10.1016/j.aninu.2022.08.013

Receive Date：2022-02-15
Online Date：2026-02-03
Published：2023-03-10

Article Data

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History

Received：2022-02-15
Revised：2022-05-15
Accepted：2022-08-09

Affiliations

^aCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

^bNano Vitamin Engineering Research Center of Shaanxi Province, Xi'an 710000, China

^cShaanxi Province Animal Husbandry Technology Extension Station, Xi'an 710016, China

Corresponding:

^* Corresponding author. E-mail address: yangxj@nwsuaf.edu.cn (X. Yang).

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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