Soybean protein concentrate causes enteritis in juvenile pearl gentian groupers (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂)

Soybean protein concentrate causes enteritis in juvenile pearl gentian groupers (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂)

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Wei Zhang^a^,^b^,^c, Beiping Tan^a^,^b^,^c^,^*, Junming Deng^a^,^b^,^c, Qihui Yang^a^,^b^,^c, Shuyan Chi^a^,^b^,^c, Aobo Pang^a^,^b^,^c, Yu Xin^a^,^b^,^c, Yu Liu^a^,^b^,^c, Haitao Zhang^c

Animal Nutrition | 2023, 12(1) : 171 - 185

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Animal Nutrition | 2023, 12(1): 171-185

• Original Research Article •

Soybean protein concentrate causes enteritis in juvenile pearl gentian groupers (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂)

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Wei Zhang^a^,^b^,^c, Beiping Tan^a^,^b^,^c^,^*, Junming Deng^a^,^b^,^c, Qihui Yang^a^,^b^,^c, Shuyan Chi^a^,^b^,^c, Aobo Pang^a^,^b^,^c, Yu Xin^a^,^b^,^c, Yu Liu^a^,^b^,^c, Haitao Zhang^c

Affiliations

^aLaboratory of Aquatic Animal Nutrition and Feed, College of Fisheries, Guangdong Ocean University, Zhanjiang, Guangdong 524088, China

^bAquatic Animals Precision Nutrition and High Efficiency Feed Engineering Research Center of Guangdong Province, Zhanjiang, Guangdong 524088, China

^cKey Laboratory of Aquatic, Livestock and Poultry Feed Science and Technology in South China, Ministry of Agriculture, Zhanjiang, Guangdong 524088, China

Published: 2023-03-10 doi: 10.1016/j.aninu.2022.08.006

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Abstract

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Due to diminishing fish meal (FM) supplies, superb protein (PRO) sources are needed for aquaculture, such as soy-based PRO. However, these can cause enteritis and even intestinal injury in fish when used at high proportions in feed. This research examines the effects of substituting soybean protein concentrate (SPC) for FM on the growth performance and intestinal balance of pearl gentian groupers and investigates the mechanism of SPC-induced enteritis. Experimental fish (n = 720) were fed 1 of 3 following diets: (1) a 50% FM diet (control), (2) a diet with 20% of the FM substituted with SPC (group SPC20), and (3) a 40% SPC-substituted diet (SPC40). Fish were fed for 10 wk iso-nitrogenous (50% PRO) and iso-lipidic (10% lipid) diets. Groups SPC20 and SPC40 showed significantly lower developmental performance and intestinal structures than control. Group SPC40 had significantly higher expressions of proinflammatory-related genes, such as interleukin 1β (IL1β), IL12, IL17 and tumor necrosis factor α and significantly lower expressions of anti-inflammatory-related genes, such as IL5, IL10 and transforming growth factor β1. Biochemical and 16S high-throughput sequencing showed that the abundance and functions of intestinal flora in group SPC40 were significantly affected (P < 0.05), and there were significant correlations between operational taxonomic unit abundance variations and inflammatory gene expressions at genus level (P < 0.05). The second- and third-generation full-length transcriptome sequence was used to analyze the mechanism of SPC-induced enteritis in pearl gentian groupers, which showed that enteritis induced by SPC may be caused by disturbances to intestinal immune function induced by an imbalance in intestinal nutrition and metabolism, such as the intestinal immunity network for IgA production pathway. However, it remains unclear as to which intestinal immune or nutritional imbalance is most important in enteritis development. This study provides a basis for further research into soy PRO-related enteritis in fish.

Key words

Epinephelus fuscoguttatus ♀ × / E. lanceolatus ♂ / Enteritis / Intestinal flora / Intestinal structure / Soybean protein concentrate

Cite this Article

Wei Zhang, Beiping Tan, Junming Deng, Qihui Yang, Shuyan Chi, Aobo Pang, Yu Xin, Yu Liu, Haitao Zhang. Soybean protein concentrate causes enteritis in juvenile pearl gentian groupers (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂)[J]. Animal Nutrition, 2023 , 12 (1) : 171 -185 . DOI: 10.1016/j.aninu.2022.08.006

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Year 2023 volume 12 Issue 1

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Article Info

doi: 10.1016/j.aninu.2022.08.006

Receive Date：2021-11-25
Online Date：2026-02-03
Published：2023-03-10

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History

Received：2021-11-25
Revised：2022-08-08
Accepted：2022-08-10

Affiliations

^aLaboratory of Aquatic Animal Nutrition and Feed, College of Fisheries, Guangdong Ocean University, Zhanjiang, Guangdong 524088, China

^bAquatic Animals Precision Nutrition and High Efficiency Feed Engineering Research Center of Guangdong Province, Zhanjiang, Guangdong 524088, China

^cKey Laboratory of Aquatic, Livestock and Poultry Feed Science and Technology in South China, Ministry of Agriculture, Zhanjiang, Guangdong 524088, China

Corresponding:

^* Corresponding author. E-mail address: bptan@126.com (B. Tan).

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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