<i>Bacillus amyloliquefaciens</i> 40 regulates piglet performance, antioxidant capacity, immune status and gut microbiota

Bacillus amyloliquefaciens 40 regulates piglet performance, antioxidant capacity, immune status and gut microbiota

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Zipeng Jiang^a^,^b^,^c^,^d^,^e, Weifa Su^a^,^b^,^c^,^d^,^e, Wentao Li^a^,^b^,^c^,^d^,^e, Chaoyue Wen^a^,^b^,^c^,^d^,^e, Shuai Du^a^,^b^,^c^,^d^,^e, Huan He^a^,^b^,^c^,^d^,^e, Yu Zhang^a^,^b^,^c^,^d^,^e, Tao Gong^a^,^b^,^c^,^d^,^e, Xinxia Wang^a^,^b^,^c^,^d^,^e, Yizhen Wang^a^,^b^,^c^,^d^,^e, Mingliang Jin^a^,^b^,^c^,^d^,^e, Zeqing Lu^a^,^b^,^c^,^d^,^e^,^*

Animal Nutrition | 2023, 12(1) : 116 - 127

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Animal Nutrition | 2023, 12(1): 116-127

• Original Research Article •

Bacillus amyloliquefaciens 40 regulates piglet performance, antioxidant capacity, immune status and gut microbiota

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Affiliations

^aNational Engineering Research Centre for Green Feed and Healthy Farming, Zhejiang University, Hangzhou, China

^bKey Laboratory of Molecular Nutrition, Ministry of Education, Zhejiang University, Hangzhou, China

^cKey Laboratory of Animal Nutrition and Feed, Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, China

^dKey Laboratory of Animal Nutrition and Feed Nutrition of Zhejiang Province, Zhejiang University, Hangzhou, China

^eCollege of Animal Science, Institute of Feed Science, Zhejiang University, Hangzhou, China

Published: 2023-03-10 doi: 10.1016/j.aninu.2022.09.006

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Abstract

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Probiotics can improve animal growth performance and intestinal health. Bacillus species, Lactobacillus species, Bifidobacterium species, yeast etc. are the common types of probiotics. However, understanding the effects of probiotics on the immune status and gut microbiota of weaning piglets and how the probiotics exert their impact are still limited. This study aimed to investigate the effects of Bacillus amyloliquefaciens 40 (BA40) on the performance, immune status and gut microbiota of piglets. A total of 12 litters of newborn piglets were randomly divided into 3 groups. Piglets in control group were orally dosed with phosphate buffered saline; BA40 group and probiotics group were orally gavaged with resuspension BA40 and a probiotics product, respectively. The results showed that BA40 treatment significantly decreased (P < 0.05) the diarrhea incidence (from d 5 to 40), diamine oxidase, D-lactate, interleukin (IL)-1β and interferon-γ concentrations compared with control group and probiotics group. Meanwhile BA40 dramatically increased the total antioxidant capacity, IL-10 and secretory immunoglobulin-A concentrations in contrast to control group. For the microbial composition, BA40 modulated the microbiota by improving the abundance of Bacteroides, Phascolarctobacterium (producing short-chain fatty acids) and Desulfovibrio and reducing the proliferation of pathogens (Streptococcus, Tyzzerella, Vellionella and paraeggerthella). Meanwhile, a metabolic function prediction explained that carbohydrate metabolism and amino acid metabolism enriched in BA40 group in contrast to control group and probiotics group. For correlation analysis, the results demonstrated that BA40-enriched Phascolarctobacterium and Desulfovibrio provide insights into strategies for elevating the health status and performance of weaned piglets. Altogether, BA40 exerted stronger ability in decreasing diarrhea incidence and improved antioxidant activity, gut barrier function and immune status of piglets than the other treatments. Our study provided the experimental and theoretical basis for the application of BA40 in pig production.

Key words

Bacillus amyloliquefaciens / Piglet / Immune status / Gut microbiota / Metabolic function

Cite this Article

Zipeng Jiang, Weifa Su, Wentao Li, Chaoyue Wen, Shuai Du, Huan He, Yu Zhang, Tao Gong, Xinxia Wang, Yizhen Wang, Mingliang Jin, Zeqing Lu. Bacillus amyloliquefaciens 40 regulates piglet performance, antioxidant capacity, immune status and gut microbiota[J]. Animal Nutrition, 2023 , 12 (1) : 116 -127 . DOI: 10.1016/j.aninu.2022.09.006

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Year 2023 volume 12 Issue 1

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Article Info

doi: 10.1016/j.aninu.2022.09.006

Receive Date：2022-02-03
Online Date：2026-02-03
Published：2023-03-10

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History

Received：2022-02-03
Revised：2022-08-17
Accepted：2022-09-16

Affiliations

^aNational Engineering Research Centre for Green Feed and Healthy Farming, Zhejiang University, Hangzhou, China

^bKey Laboratory of Molecular Nutrition, Ministry of Education, Zhejiang University, Hangzhou, China

^cKey Laboratory of Animal Nutrition and Feed, Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou, China

^dKey Laboratory of Animal Nutrition and Feed Nutrition of Zhejiang Province, Zhejiang University, Hangzhou, China

^eCollege of Animal Science, Institute of Feed Science, Zhejiang University, Hangzhou, China

Corresponding:

^* Corresponding author. E-mail address: zqlu2012@zju.edu.cn (Z. Lu).

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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