Animal Models and Experimental Medicine

Animal Models and Experimental Medicine ›› 2026, Vol. 9 ›› Issue (7) : 1373 - 1394. DOI: 10.1002/ame2.70230

Regular Articles

Chrysin alleviates pressure overload-induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway-mediated oxidative stress response

Yijia Wang ¹ ,
Xing Feng ¹ ,
Shuhui Zhao ¹ ,
Yuchong Fu ¹ ,
Ao Zhang ¹ ,
Xiaofeng Shen ² ,
Bowen Yu ² ,
Yihao Wang ² ,
Jiahui Lin ² ,
Bing Zhang ³ ,
Weiping Ji ²^,⁴ ,
Lianpin Wu ⁵^,⁶ ,
Xiaoling Guo ¹^,⁵^,⁶

Author information +

¹Basic Medical Research Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China

²Department of General Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China

³Engineering Research Center of Techniques and Instruments for Diagnosis and Treatment of Congenital Heart Disease, Institute of Developmental and Regenerative Medicine, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

⁴National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

⁵Zhejiang-Ireland Joint Laboratory for Precision Diagnosis and Treatment of Valvular Heart Diseases, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

⁶Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

Weiping Ji, Department of General Surgery, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Email: jiweiping19841022@126.com

Lianpin Wu, Zhejiang-Ireland Joint Laboratory for Precision Diagnosis and Treatment of Valvular Heart Diseases, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Email: 198019@wzhealth.com

Xiaoling Guo, Basic Medical Research Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou 325027, Zhejiang, China. Email: guoxling@wmu.edu.cn

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Received	Accepted	Published
2026-01-11	2026-05-03
Issue Date
2026-08-06

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