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Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy
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Hira Khan1, Khushbakhat Alia1, Yusra Al Dhaheri1, Muhammad Naseem2, 3, Rabah Iratni1, Edgar Serfling4, Khalid Muhammad1, 5
Animal Models and Experimental Medicine | 2026, 9(7) : 1338 - 1352
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Animal Models and Experimental Medicine | 2026, 9(7): 1338-1352
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Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy
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Hira Khan1, Khushbakhat Alia1, Yusra Al Dhaheri1, Muhammad Naseem2, 3, Rabah Iratni1, Edgar Serfling4, Khalid Muhammad1, 5
Affiliations
  • 1Department of Biology, College of Science, United Arab Emirates University, Al Ain, UAE
  • 2Department of Environmental Science and Sustainability, College of Natural and Health Sciences, Zayed University, Abu Dhabi, UAE
  • 3Department of Bioinformatics, Biozentrum Am Hubland, University of Würzburg, Würzburg, Germany
  • 4Department of Pathology, University of Würzburg, Würzburg, Germany
  • 5Zayed Bin Sultan Al Nahyan Center for Health Sciences, United Arab Emirates University, Al Ain, UAE
Published: 2026-07-28 doi: 10.1002/ame2.70251
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The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors. Numerous biological processes including angiogenesis, invasion, migration, proliferation, and cell survival are regulated by the NFAT family. NFATs are overexpressed and have increased transcriptional activity in a variety of human solid tumors and hematological cancers. Beyond tumor cell-intrinsic roles, NFAT has also emerged as an important regulator of the tumor microenvironment (TME), where it can influence immune cell behavior and contribute to mechanisms of immune evasion. The discovery of the multifaceted functions of NFATs has driven the need to further unveil their role in cancer and provide new insights into other potential roles. This review provides a comprehensive narrative synthesis of current molecular and clinical studies, with particular emphasis on how NFAT shapes tumor immune interactions and modulates the TME. By integrating findings across different cancer types, we highlight how NFAT may contribute to both tumor progression and immune regulation. The review concludes by highlighting significant knowledge gaps and recommending future paths for translational and therapeutic research to leverage NFAT signaling as a potential target in precision cancer therapy.

cancer progression  /  immune evasion  /  nuclear factor of activated T cells (NFAT)  /  precision cancer therapy  /  tumor microenvironment (TME)
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad. Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy[J]. Animal Models and Experimental Medicine, 2026 , 9 (7) : 1338 -1352 . DOI: 10.1002/ame2.70251
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Funding
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  • UAE University(G-4960; G-5310; G-5500)
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Year 2026 volume 9 Issue 7
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31
9
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Article Info
doi: 10.1002/ame2.70251
  • Receive Date：2026-01-30
  • Online Date：2026-08-06
  • Published：2026-07-28
Article Data
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History
  • Received：2026-01-30
  • Revised：2026-05-20
  • Accepted：2026-05-31
Funding
UAE University(G-4960; G-5310; G-5500)
Affiliations
    1Department of Biology, College of Science, United Arab Emirates University, Al Ain, UAE
    2Department of Environmental Science and Sustainability, College of Natural and Health Sciences, Zayed University, Abu Dhabi, UAE
    3Department of Bioinformatics, Biozentrum Am Hubland, University of Würzburg, Würzburg, Germany
    4Department of Pathology, University of Würzburg, Würzburg, Germany
    5Zayed Bin Sultan Al Nahyan Center for Health Sciences, United Arab Emirates University, Al Ain, UAE

Corresponding:

Khalid Muhammad, Department of Biology, College of Science, United Arab Emirates University, Al Ain 15551, United Arab Emirates. Email:
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表12种不同金属材料的力学参数
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Number of
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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