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GS-9620 alleviates psoriasis-like inflammation by regulating autophagy in keratinocytes
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Yansi Lyu1, Wei Zhou2, Pei Zhang3, Chen Lin2, Xin Wen2, Zigang Zhao4, Guoqiang Zhang5, Qian Zhang6, Si Chen2
Animal Models and Experimental Medicine | 2026, 9(7) : 1364 - 1372
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Animal Models and Experimental Medicine | 2026, 9(7): 1364-1372
• Regular Articles •
GS-9620 alleviates psoriasis-like inflammation by regulating autophagy in keratinocytes
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Yansi Lyu1, Wei Zhou2, Pei Zhang3, Chen Lin2, Xin Wen2, Zigang Zhao4, Guoqiang Zhang5, Qian Zhang6, Si Chen2
Affiliations
  • 1Department of Dermatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, P. R. China
  • 2Department of Immunology, Shenzhen University Medical School, Shenzhen, Guangdong, P. R. China
  • 3Department of Pathology, Affiliated Hospital of Hebei University, Baoding, Hebei, P. R. China
  • 4Department of Dermatology, Hainan Hospital of PLA General Hospital, Sanya, Hainan, P. R. China
  • 5Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, P. R. China
  • 6Department of Dermatology, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, P. R. China
Published: 2026-07-28 doi: 10.1002/ame2.70222
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Background:

Psoriasis is an immune-driven dermatosis marked by keratinocyte hyperproliferation. GS-9620, a TLR7 agonist, previously mitigated EV71-triggered inflammation in mice; here we probe its anti-psoriatic potential and mechanisms.

Methods:

IMQ-induced psoriasis-like mice were treated with GS-9620 or MTX; severity was tracked by PASI and histology. Skin/spleen cytokines (IL-1β, IL-6, IL-18, HMGB1, TNF-α) were quantified via ELISA; immune subsets were quantified by flow cytometry. Autophagy proteins (ATG5/12/16 L1) and NLRP3 were assessed by IHC/Western blot. In vitro, M5-stimulated primary keratinocytes were treated with GS-9620 ± autophagy modulators, followed by cytokine and protein analyses.

Results:

GS-9620 markedly reduced erythema, scaling and epidermal thickness, lowered skin and systemic cytokines, and decreased splenic CD3+/CD4+IL-17A+ cells. It restored ATG5/12/16 L1 expression while suppressing NLRP3 both in lesions and in M5-stimulated keratinocytes, leading to diminished IL-1β, IL-6, IL-18, HMGB1 and TNF-α release.

Conclusions:

GS-9620 alleviates psoriasis by enhancing autophagy and dampening NLRP3-mediated inflammation, offering a promising therapeutic avenue.

anti-psoriasis drugs  /  autophagy  /  GS-9620  /  NLRP3  /  PASI  /  psoriasis
Yansi Lyu, Wei Zhou, Pei Zhang, Chen Lin, Xin Wen, Zigang Zhao, Guoqiang Zhang, Qian Zhang, Si Chen. GS-9620 alleviates psoriasis-like inflammation by regulating autophagy in keratinocytes[J]. Animal Models and Experimental Medicine, 2026 , 9 (7) : 1364 -1372 . DOI: 10.1002/ame2.70222
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Funding
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  • Science, Technology and Innovation Commission of Shenzhen Municipality(JCYJ20220530141615035; 20231120113324002)
  • Guangdong Provincial Enterprise Joint Fund-General Program(2022A1515220137)
  • HaiYa Young Scientist Foundation of Shenzhen University General Hospital(2024-HY004)
  • Shenzhen Medical Research Fund(A2401029)
Appendix
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Year 2026 volume 9 Issue 7
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41
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Article Info
doi: 10.1002/ame2.70222
  • Receive Date：2025-12-17
  • Online Date：2026-08-06
  • Published：2026-07-28
Article Data
Affiliations
History
  • Received：2025-12-17
  • Revised：2026-04-01
  • Accepted：2026-04-14
Funding
Science, Technology and Innovation Commission of Shenzhen Municipality(JCYJ20220530141615035; 20231120113324002)
Guangdong Provincial Enterprise Joint Fund-General Program(2022A1515220137)
HaiYa Young Scientist Foundation of Shenzhen University General Hospital(2024-HY004)
Shenzhen Medical Research Fund(A2401029)
Affiliations
    1Department of Dermatology, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, P. R. China
    2Department of Immunology, Shenzhen University Medical School, Shenzhen, Guangdong, P. R. China
    3Department of Pathology, Affiliated Hospital of Hebei University, Baoding, Hebei, P. R. China
    4Department of Dermatology, Hainan Hospital of PLA General Hospital, Sanya, Hainan, P. R. China
    5Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, P. R. China
    6Department of Dermatology, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, P. R. China

Corresponding:

Guoqiang Zhang, Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P. R. China. Email:
Qian Zhang, Department of Dermatology, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong 518000, P. R. China. Email:
Si Chen, Shenzhen University Medical School, Shenzhen, Guangdong 518055, P. R. China. Email:
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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