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Choerospondias axillaris: a review of its clinical application, phytochemistry, and an investigation into its potential cardiovascular therapy
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Yanfei Huang1, 2, Qi Ye1, Yifan Tian2, Li Yang2, Zhiyan Liu1, Liping Bai1, Yuan Liu2, Zhifeng Zhang1, 2, Weiyi Tian3, Pei Luo1, 4, *
Acupuncture and Herbal Medicine | 2025, 5(2) : 246 - 269
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Acupuncture and Herbal Medicine | 2025, 5(2): 246-269
• Hundred of herbs •
Choerospondias axillaris: a review of its clinical application, phytochemistry, and an investigation into its potential cardiovascular therapy
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Yanfei Huang1, 2, Qi Ye1, Yifan Tian2, Li Yang2, Zhiyan Liu1, Liping Bai1, Yuan Liu2, Zhifeng Zhang1, 2, Weiyi Tian3, Pei Luo1, 4, *
Affiliations
  • 1State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China
  • 2Qinghai-Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China, Southwest Minzu University, Chengdu, China
  • 3Department of Immunology and Microbiology, School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China
  • 4Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou, China
About Author:

Yanfei Huang and Qi Ye contributed equally to this work.

Published: 2025-06-25 doi: 10.1097/HM9.0000000000000157
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This article conducts a comprehensive review of both traditional therapeutic application knowledge and contemporary literature pertaining to Choerospondias axillaris (Roxb.) Burtt et Hill. Traditional application information was gathered from relevant reports, books, and classic material medica. Research literature and dissertations on C. axillaris chemical constituents and pharmacological activities, available up to 2023, were sourced from electronic databases. Pharmaceutical components such as flavonoids, phenolic acids, triterpenes, lignans, and organic acids were identified in C. axillaris and categorized based on their relevance to cardiovascular roles. Examining the material basis for C. axillaris efficacy in addressing cardiovascular diseases, an analysis of 27 Chinese patent medicines containing Choerospondiatis Fructus (CF) highlighted Myristicae Semen as the most frequently utilized and strongly associated with CF in prescriptions. C. axillaris exhibited notable pharmacological effects, encompassing anti-myocardial ischemia-reperfusion injury, anti-arrhythmic properties, anti-myocardial fibrosis, and hemorheological effects linked to cardiovascular diseases. This review aspires to provide valuable insights for translating traditional applications into modern pharmaceuticals and offers guidance for clinical applications in cardiovascular interventions.

Bioactive components  /  Cardiovascular diseases  /  Choerospondias axillaris  /  Traditional therapeutic application
Yanfei Huang, Qi Ye, Yifan Tian, Li Yang, Zhiyan Liu, Liping Bai, Yuan Liu, Zhifeng Zhang, Weiyi Tian, Pei Luo. Choerospondias axillaris: a review of its clinical application, phytochemistry, and an investigation into its potential cardiovascular therapy[J]. Acupuncture and Herbal Medicine, 2025 , 5 (2) : 246 -269 . DOI: 10.1097/HM9.0000000000000157
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Funding
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  • Macau Science and Technology Development Fund(0043/2021/AGJ)
  • Science and Technology Major Project of Tibetan Autonomous Region of China(XZ202201ZD0001G06)
  • Natural Science Foundation of Sichuan Province(2022NSFSC1605)
  • Special Fund of Natural Science for the Central Universities(ZYN2023099)
  • Engineering Research Center for Pharmaceuticals and Equipments of Sichuan Province Fund(ERCPEF2201)
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Year 2025 volume 5 Issue 2
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Article Info
doi: 10.1097/HM9.0000000000000157
  • Receive Date：2024-09-10
  • Online Date：2026-11-04
  • Published：2025-06-25
Article Data
Affiliations
History
  • Received：2024-09-10
  • Accepted：2025-04-14
Funding
Macau Science and Technology Development Fund(0043/2021/AGJ)
Science and Technology Major Project of Tibetan Autonomous Region of China(XZ202201ZD0001G06)
Natural Science Foundation of Sichuan Province(2022NSFSC1605)
Special Fund of Natural Science for the Central Universities(ZYN2023099)
Engineering Research Center for Pharmaceuticals and Equipments of Sichuan Province Fund(ERCPEF2201)
Affiliations
    1State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China
    2Qinghai-Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China, Southwest Minzu University, Chengdu, China
    3Department of Immunology and Microbiology, School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China
    4Guangdong-Hong Kong-Macao Universities Joint Laboratory for the Internationalization of Traditional Chinese Medicine, Guangzhou, China

Corresponding:

* Pei Luo, E-mail: .
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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