Home Journals Articles Updates About
CN
image
收藏切换
Electroacupuncture at BL15 improved arrhythmia-induced cardiomyopathy associated with restoring disordered conduction and calcium handling
收藏切换
PDF
Shengxuan Sun1, 2, Jing Huang2, Yijun Hu1, 3, Yang Su2, Huanhuan Yu1, 3, Feng Guo1, 3, Meng Zhang1, 3, 4, Yucen Xia1, 3, 4, Lin Yao1, 3, 4, Taiyi Wang1, 3, 4, *, Yongjun Chen1, 3, 4, *
Acupuncture and Herbal Medicine | 2025, 5(3) : 338 - 351
Less
收藏切换
Acupuncture and Herbal Medicine | 2025, 5(3): 338-351
• Original Articles •
Electroacupuncture at BL15 improved arrhythmia-induced cardiomyopathy associated with restoring disordered conduction and calcium handling
Full
Shengxuan Sun1, 2, Jing Huang2, Yijun Hu1, 3, Yang Su2, Huanhuan Yu1, 3, Feng Guo1, 3, Meng Zhang1, 3, 4, Yucen Xia1, 3, 4, Lin Yao1, 3, 4, Taiyi Wang1, 3, 4, *, Yongjun Chen1, 3, 4, *
Affiliations
  • 1Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China
  • 2South China Research Center for Acupuncture and Moxibustion, Medical College of AcuMoxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China
  • 3Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
  • 4Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China
About Author:

Shengxuan Sun, Jing Huang, and Yijun Hu contributed equally to this work.

Published: 2025-09-25 doi: 10.1097/HM9.0000000000000169
Outline
收藏切换
Objective:

Arrhythmia-induced cardiomyopathy (AIC) is a reversible dilated cardiomyopathy induced by rapid or irregular heartbeat. Acupuncture has a long history of use in the treatment of cardiac diseases, and Xinshu (BL15) is a key acupoint. However, the underlying mechanism of acupuncture at BL15 in the treatment of AIC has not yet been elucidated.

Methods:

AIC was induced in adult male Sprague-Dawley (SD) rats by continuous administration of acetylcholine (ACh)-CaCl2 and treatment with electroacupuncture (EA) at bilateral BL15. Echocardiography was used to evaluate cardiac function; the rotarod test for motor coordination and performance; hematoxylin and eosin (HE) staining for the morphology of ventricles; electrocardiogram for susceptibility, inducibility, and duration of atrial fibrillation (AF); and electrical and optical mapping in isolated rat hearts maintained by the Langendorff perfusion system for electrical conduction and intracellular handling, respectively. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting were used to determine the levels of cardiac conduction and intracellular calcium-handling proteins in the ventricle.

Results:

The results showed that EA improved the ejection factor and morphological indices on echocardiography, restored motor coordination and performance, and alleviated ventricular dilation and AF onset. EA alleviates atrial conduction disorders, shortens APD80, and decreases calcium handling in rats with AIC. Cx43 was downregulated and CaMKII was upregulated, and both effects were reversed by EA treatment.

Conclusion:

Our study provides a novel AIC model with abnormal electrical propagation and calcium handling that can be protected by EA at BL15. This potential mechanism may be associated with the modulation of Cx43 and CaMKII expression.

Arrhythmia-induced cardiomyopathy  /  BL15  /  Calcium handling  /  Cardiac conduction  /  Electroacupuncture
Shengxuan Sun, Jing Huang, Yijun Hu, Yang Su, Huanhuan Yu, Feng Guo, Meng Zhang, Yucen Xia, Lin Yao, Taiyi Wang, Yongjun Chen. Electroacupuncture at BL15 improved arrhythmia-induced cardiomyopathy associated with restoring disordered conduction and calcium handling[J]. Acupuncture and Herbal Medicine, 2025 , 5 (3) : 338 -351 . DOI: 10.1097/HM9.0000000000000169
Full Text
Less
Funding
Less
  • National Key R&D Program of China(2022YFC3500405; 2019YFC1712105)
  • The National Science Foundation of China(82374075)
  • The National Comprehensive Traditional Chinese Medicine Reform Demonstration Zone Science and Technology Collaborative Development Project(GZY-KJS-SD-2024-046)
  • Taishan Scholar Youth Project of Shandong Province(tsqn202306188)
Appendix
Less
Year 2025 volume 5 Issue 3
PDF
2
0
Cite this Article
BibTeX
Article Info
doi: 10.1097/HM9.0000000000000169
  • Receive Date：2025-02-12
  • Online Date：2026-11-04
  • Published：2025-09-25
Article Data
Affiliations
History
  • Received：2025-02-12
  • Accepted：2025-08-23
Funding
National Key R&D Program of China(2022YFC3500405; 2019YFC1712105)
The National Science Foundation of China(82374075)
The National Comprehensive Traditional Chinese Medicine Reform Demonstration Zone Science and Technology Collaborative Development Project(GZY-KJS-SD-2024-046)
Taishan Scholar Youth Project of Shandong Province(tsqn202306188)
Affiliations
    1Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China
    2South China Research Center for Acupuncture and Moxibustion, Medical College of AcuMoxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China
    3Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
    4Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China

Corresponding:

* Yongjun Chen, E-mail: ;
Taiyi Wang, E-mail: .
References
Share
https://castjournals.cast.org.cn/joweb/ahm/EN/10.1097/HM9.0000000000000169
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House