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Research progress on non-pharmacological therapies of traditional medicine for depression
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Qing Zhou1, Ningyi Zou1, Yanan Zhao1, Gerhard Litscher2, Yuzhengheng Zhang1, Ruoyi Wu1, Guojian Gao3, *, Shaoyuan Li1, *
Acupuncture and Herbal Medicine | 2025, 5(3) : 277 - 290
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Acupuncture and Herbal Medicine | 2025, 5(3): 277-290
• Review Article •
Research progress on non-pharmacological therapies of traditional medicine for depression
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Qing Zhou1, Ningyi Zou1, Yanan Zhao1, Gerhard Litscher2, Yuzhengheng Zhang1, Ruoyi Wu1, Guojian Gao3, *, Shaoyuan Li1, *
Affiliations
  • 1Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China
  • 2Swiss University of Traditional Chinese Medicine, Bad Zurzach, Switzerland
  • 3Graduate School, China Academy of Chinese Medical Sciences, Beijing, China
Published: 2025-09-25 doi: 10.1097/HM9.0000000000000168
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Depression is a prevalent neuropsychiatric disorder characterized by persistent sadness, anhedonia, guilt, fatigue, and impaired concentration. Although pharmacotherapy and psychotherapy can be effective, their utility is limited by adverse effects and significant inter-individual variability. Non-pharmacological therapies from traditional medicine have emerged as promising adjuncts owing to their favorable safety profiles, minimal side effects, and high patient compliance. These therapies, including acupoint stimulation, meditation, and yoga, produce antidepressant effects by reducing neuroinflammation, modulating neurotransmitter release, enhancing neuroplasticity, and regulating the gut-brain axis. This review summarizes clinical applications and mechanistic insights of traditional medicine's non-pharmacological therapies for depression, providing a scientific rationale for their integration into comprehensive management.

Clinical applications  /  Depression  /  Non-pharmacological therapies  /  Research progress  /  Traditional medicine
Qing Zhou, Ningyi Zou, Yanan Zhao, Gerhard Litscher, Yuzhengheng Zhang, Ruoyi Wu, Guojian Gao, Shaoyuan Li. Research progress on non-pharmacological therapies of traditional medicine for depression[J]. Acupuncture and Herbal Medicine, 2025 , 5 (3) : 277 -290 . DOI: 10.1097/HM9.0000000000000168
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Funding
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  • Beijing Natural Science Foundation(7244491)
  • Beijing TCM Science and Technology Development Fund Project(BJZYON-2023-05)
  • Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-048; ZZ-YQ2023006)
  • Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202409)
  • Technology Innovation Project of the Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences(CIZJS2025023)
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Year 2025 volume 5 Issue 3
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Article Info
doi: 10.1097/HM9.0000000000000168
  • Receive Date：2025-04-09
  • Online Date：2026-11-04
  • Published：2025-09-25
Article Data
Affiliations
History
  • Received：2025-04-09
  • Accepted：2025-08-21
Funding
Beijing Natural Science Foundation(7244491)
Beijing TCM Science and Technology Development Fund Project(BJZYON-2023-05)
Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-048; ZZ-YQ2023006)
Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202409)
Technology Innovation Project of the Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences(CIZJS2025023)
Affiliations
    1Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China
    2Swiss University of Traditional Chinese Medicine, Bad Zurzach, Switzerland
    3Graduate School, China Academy of Chinese Medical Sciences, Beijing, China

Corresponding:

* Shaoyuan Li, E-mail: ;
Guojian Gao, E-mail: .
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