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The interactions between gut microbiota and Chinese herbal medicine in colorectal cancer
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Xinxin Hou1, Xinyi Li1, 2, Wanqing Chen2, Weikang Zhu2, Haidong Guo1, *, Ling Zhao1, *
Acupuncture and Herbal Medicine | 2025, 5(2) : 147 - 159
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Acupuncture and Herbal Medicine | 2025, 5(2): 147-159
• Review Articles •
The interactions between gut microbiota and Chinese herbal medicine in colorectal cancer
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Xinxin Hou1, Xinyi Li1, 2, Wanqing Chen2, Weikang Zhu2, Haidong Guo1, *, Ling Zhao1, *
Affiliations
  • 1School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • 2Department of Oncology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China
About Author:

Xinxin Hou and Xinyi Li contributed equally to this work.

Published: 2025-06-25 doi: 10.1097/HM9.0000000000000153
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Chinese herbal medicine (CHM), with a range of pharmacological and molecular targets, has unique advantages in the comprehensive treatment of colorectal cancer (CRC); however, its clinical application remains limited owing to undetermined anti-CRC mechanisms. Recent studies have shown that gut microbes mediate the intestinal barrier, metabolism, and immunity, which, in turn, affect CRC initiation, progression, and CHM therapy. Here, we summarize the mechanisms and clinical applications of the gut microbiota involved in CRC, together with the latest studies of CHM in CRC therapy and its anti-tumor molecular basis from the gut microbiota perspective. This review highlights the gut microbiota as a "bridge" to clarify the scientific of CHM in treating CRC. More efforts should be focused on how the gut microbiome interacts with CHM to elucidate the mechanism of action of CHM and provide a more applicable basis for CHM- and microbiota-related therapies for the treatment of CRC.

Chinese herbal medicine  /  Colorectal cancer  /  Gut microbiota  /  Mucosal immunity  /  Tumor microenvironment
Xinxin Hou, Xinyi Li, Wanqing Chen, Weikang Zhu, Haidong Guo, Ling Zhao. The interactions between gut microbiota and Chinese herbal medicine in colorectal cancer[J]. Acupuncture and Herbal Medicine, 2025 , 5 (2) : 147 -159 . DOI: 10.1097/HM9.0000000000000153
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Funding
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  • National Natural Science Foundation of China(82104955; 82205223)
  • Shanghai Rising-Star Program(22QA1408700; 21YF1444500)
  • China Postdoctoral Science Foundation(2022M712154)
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Year 2025 volume 5 Issue 2
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Article Info
doi: 10.1097/HM9.0000000000000153
  • Receive Date：2024-09-18
  • Online Date：2026-11-04
  • Published：2025-06-25
Article Data
Affiliations
History
  • Received：2024-09-18
  • Accepted：2025-03-25
Funding
National Natural Science Foundation of China(82104955; 82205223)
Shanghai Rising-Star Program(22QA1408700; 21YF1444500)
China Postdoctoral Science Foundation(2022M712154)
Affiliations
    1School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    2Department of Oncology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China

Corresponding:

* Haidong Guo, E-mail: ;
Ling Zhao, E-mail: .
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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