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Research progress regarding endocannabinoid system involvement in pain modulation and electroacupuncture analgesia
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Renjie Qin1, Yisong Wu1, Nuo Jin1, Xingzhi Xu1, Yuye Lan1, Xianghong Jing2, Man Li1, *
Acupuncture and Herbal Medicine | 2025, 5(1) : 36 - 45
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Acupuncture and Herbal Medicine | 2025, 5(1): 36-45
• Review Articles •
Research progress regarding endocannabinoid system involvement in pain modulation and electroacupuncture analgesia
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Renjie Qin1, Yisong Wu1, Nuo Jin1, Xingzhi Xu1, Yuye Lan1, Xianghong Jing2, Man Li1, *
Affiliations
  • 1School of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, China
  • 2Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China
Published: 2025-03-25 doi: 10.1097/HM9.0000000000000142
Outline
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Pain is a subjective and unpleasant sensation that significantly impacts the daily lives of individuals. Chronic pain represents one of the most challenging public health issues, and ensuring effective pain management is a fundamental right of individuals and a sacred duty of healthcare providers. Cannabis, one of the earliest recognized medicinal plants, contains cannabinoids, which are non-opioid substances that modulate nociceptive responses. Electroacupuncture (EA), characterized by its low-risk and well-tolerated nature, is pivotal in pain management. The endocannabinoid system consists of endocannabinoids, cannabinoid receptors, and enzymes involved in endocannabinoid synthesis, degradation, and transport. Recently, the role of the endocannabinoid system in pain development and EA analgesia has attracted considerable research attention. Studies have highlighted the role of the endocannabinoid system in various types of pain, including inflammatory pain, neuropathic pain, and cancer-related pain, as well as in EA analgesia. This study aims to review the mechanisms of endocannabinoid system involvement in pain modulation and EA analgesia to provide insights to inform clinical approaches to pain management.

Electroacupuncture  /  Endocannabinoid receptors  /  Inflammatory pain  /  Neuropathic pain
Renjie Qin, Yisong Wu, Nuo Jin, Xingzhi Xu, Yuye Lan, Xianghong Jing, Man Li. Research progress regarding endocannabinoid system involvement in pain modulation and electroacupuncture analgesia[J]. Acupuncture and Herbal Medicine, 2025 , 5 (1) : 36 -45 . DOI: 10.1097/HM9.0000000000000142
  • Key Program of the National Natural Science Foundation of China(82130122)
  • National Natural Science Foundation of China(81973949)
Year 2025 volume 5 Issue 1
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Article Info
doi: 10.1097/HM9.0000000000000142
  • Receive Date:2024-04-21
  • Online Date:2026-11-04
  • Published:2025-03-25
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History
  • Received:2024-04-21
  • Accepted:2025-01-21
Funding
Key Program of the National Natural Science Foundation of China(82130122)
National Natural Science Foundation of China(81973949)
Affiliations
    1School of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, China
    2Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China

Corresponding:

* Man Li, E-mail: .
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表12种不同金属材料的力学参数
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Family
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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