Pain is a subjective and unpleasant sensation that significantly impacts the daily lives of individuals. Chronic pain represents one of the most challenging public health issues, and ensuring effective pain management is a fundamental right of individuals and a sacred duty of healthcare providers. Cannabis, one of the earliest recognized medicinal plants, contains cannabinoids, which are non-opioid substances that modulate nociceptive responses. Electroacupuncture (EA), characterized by its low-risk and well-tolerated nature, is pivotal in pain management. The endocannabinoid system consists of endocannabinoids, cannabinoid receptors, and enzymes involved in endocannabinoid synthesis, degradation, and transport. Recently, the role of the endocannabinoid system in pain development and EA analgesia has attracted considerable research attention. Studies have highlighted the role of the endocannabinoid system in various types of pain, including inflammatory pain, neuropathic pain, and cancer-related pain, as well as in EA analgesia. This study aims to review the mechanisms of endocannabinoid system involvement in pain modulation and EA analgesia to provide insights to inform clinical approaches to pain management.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |