PDF
Full
Outline
Network pharmacology provides a transformative framework for decoding multi-target, system-level mechanisms of the food-medicine homology (FMH) substances, overcoming the limitations of reductionist approaches by integrating multi-omics data, computational modeling, and network analysis. Central to this paradigm is the "Network Targets" theory, which conceptualizes therapeutic intervention as the reconfiguration of disease-associated biological networks rather than the modulation of isolated single targets. Artificial intelligence accelerates this process by enabling high-dimensional data integration, predictive modeling of synergistic combinations, and the identification of active constituents. This review outlines the key databases and computational tools that operationalize network pharmacology in FMH research and systematically categorizes their applications, including material screening, ingredient identification, synergy analysis, quality standard establishment, safety assessment, formula optimization, functional food discovery, and personalized recommendation, supported by experimental validation across numerous FMH items. Despite the challenges in data standardization and dynamic modeling, the integration of multi-omics, dynamic networks, and centralized repositories will further advance the field. Ultimately, network pharmacology will bridge traditional FMH wisdom with contemporary mechanistic rigor, positioning FMH as the cornerstone of precision nutrition and preventive medicine.
PDF
6
0
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
