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Oridonin mitigates cerebral ischemic-reperfusion injury via covalent binding to HMGB1 and inhibiting the HMGB1/TLR4/MyD88/NF-κB signaling pathway
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Dandan Liu1, Shujie Zhang1, Fei Xia1, Qiaoli Shi1, Hui Zhao2, Yinkwan Wong3, Yuqing Meng1, Yanqing Liu1, Yongping Zhu1, Xin Chai1, Jiale Xing1, Huan Tang1, Chong Qiu1, Peili Wang4, *, Ang Ma1, *, Jigang Wang1, *
Acupuncture and Herbal Medicine | 2026, 6(1) : 56 - 72
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Acupuncture and Herbal Medicine | 2026, 6(1): 56-72
• Original Article •
Oridonin mitigates cerebral ischemic-reperfusion injury via covalent binding to HMGB1 and inhibiting the HMGB1/TLR4/MyD88/NF-κB signaling pathway
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Dandan Liu1, Shujie Zhang1, Fei Xia1, Qiaoli Shi1, Hui Zhao2, Yinkwan Wong3, Yuqing Meng1, Yanqing Liu1, Yongping Zhu1, Xin Chai1, Jiale Xing1, Huan Tang1, Chong Qiu1, Peili Wang4, *, Ang Ma1, *, Jigang Wang1, *
Affiliations
  • 1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
  • 2School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
  • 3Department of Physiological Sciences, National University of Singapore, Singapore, Singapore
  • 4National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Published: 2026-03-25 doi: 10.1097/HM9.0000000000000181
Outline
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Cerebral ischemic-reperfusion injury  /  Chemical proteomics  /  HMGB1  /  Oridonin  /  Target discovery
Dandan Liu, Shujie Zhang, Fei Xia, Qiaoli Shi, Hui Zhao, Yinkwan Wong, Yuqing Meng, Yanqing Liu, Yongping Zhu, Xin Chai, Jiale Xing, Huan Tang, Chong Qiu, Peili Wang, Ang Ma, Jigang Wang. Oridonin mitigates cerebral ischemic-reperfusion injury via covalent binding to HMGB1 and inhibiting the HMGB1/TLR4/MyD88/NF-κB signaling pathway[J]. Acupuncture and Herbal Medicine, 2026 , 6 (1) : 56 -72 . DOI: 10.1097/HM9.0000000000000181
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Funding
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  • National Natural Science Foundation of China(82204672)
  • Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2023E002)
  • Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-063)
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Year 2026 volume 6 Issue 1
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Article Info
doi: 10.1097/HM9.0000000000000181
  • Receive Date：2025-05-30
  • Online Date：2026-06-05
  • Published：2026-03-25
Article Data
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History
  • Received：2025-05-30
  • Accepted：2026-01-22
Funding
National Natural Science Foundation of China(82204672)
Scientific and technological innovation project of China Academy of Chinese Medical Sciences(CI2023E002)
Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-063)
Affiliations
    1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
    2School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
    3Department of Physiological Sciences, National University of Singapore, Singapore, Singapore
    4National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China

Corresponding:

* Corresponding author. Peili Wang, E-mail:
Ang Ma, E-mail:
Jigang Wang, E-mail: .
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表12种不同金属材料的力学参数
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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