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Puerariae Lobatae Radix: botanical traits, chemical constituents, and anti-metabolic disease effects—a review
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Xintao Chen1, Ni Zhang1, Wenting Wu1, Jing Liu1, Qiong Li1, Zhenzhong Zang1, Hui Ouyang1, Huanhuan Dong1, Xu Zhou1, Xiaowei Meng1, Olga Maria Duarte Silva2, Bo Wu1, Yongmei Guan1, 3, *, Jiwen Zhang1, 4, *, Weifeng Zhu1, *
Acupuncture and Herbal Medicine | 2026, 6(1) : 119 - 138
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Acupuncture and Herbal Medicine | 2026, 6(1): 119-138
• Hundreds of Herbs •
Puerariae Lobatae Radix: botanical traits, chemical constituents, and anti-metabolic disease effects—a review
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Xintao Chen1, Ni Zhang1, Wenting Wu1, Jing Liu1, Qiong Li1, Zhenzhong Zang1, Hui Ouyang1, Huanhuan Dong1, Xu Zhou1, Xiaowei Meng1, Olga Maria Duarte Silva2, Bo Wu1, Yongmei Guan1, 3, *, Jiwen Zhang1, 4, *, Weifeng Zhu1, *
Affiliations
  • 1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, China
  • 2Universidade de Lisboa, Alameda da Universidade, Cidade Universitária, Portugal
  • 3National Key Laboratory for the Creation of Classic Prescriptions and Modern Traditional Chinese Medicine, Nanchang, China
  • 4Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Published: 2026-03-25 doi: 10.1097/HM9.0000000000000194
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Puerariae Lobatae Radix (PLR) is a traditional Chinese medicinal herb included in China's inaugural list of substances recognized as both food and medicine. PLR has a long history of use and a wide range of medicinal applications. Its use is associated with a broad range of health-promoting effects. Recent studies have shown that PLR contains abundant bioactive compounds including isoflavones and polysaccharides. These findings demonstrate significant potential for the prevention and treatment of metabolic diseases (MDs). The potential mechanisms underlying these effects involve several targets and pathways, including activation of the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and AMPK signaling pathways; regulation of key factors, such as peroxisome proliferator-activated receptors; and modulation of the gut microbiota composition. This systematic review examines the botanical characteristics and primary chemical constituents of PLR, with particular emphasis on recent research advances, mechanisms of action, and the clinical applications of its active components in MDs intervention. This review aims to provide theoretical guidance for further development, quality improvement, and application of PLR in the prevention and treatment of MDs.

Botanical characteristics  /  Chemical constituents  /  Clinical applications  /  Metabolic diseases  /  Puerariae Lobatae Radix
Xintao Chen, Ni Zhang, Wenting Wu, Jing Liu, Qiong Li, Zhenzhong Zang, Hui Ouyang, Huanhuan Dong, Xu Zhou, Xiaowei Meng, Olga Maria Duarte Silva, Bo Wu, Yongmei Guan, Jiwen Zhang, Weifeng Zhu. Puerariae Lobatae Radix: botanical traits, chemical constituents, and anti-metabolic disease effects—a review[J]. Acupuncture and Herbal Medicine, 2026 , 6 (1) : 119 -138 . DOI: 10.1097/HM9.0000000000000194
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Funding
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  • Development of a Major Chinese Herbal Medicine Species, Pueraria montana (Lour.). Merr (Pueraria lobata, Puerariae thom-sonii)(2017YFC1702900)
  • Key R&D Program of Jiangxi Province(20224BBG71023)
  • National Key R&D Program(2024YFE0104600)
  • National Administration of Traditional Chinese Medicine Project(GZY-KJS-2023-033)
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Year 2026 volume 6 Issue 1
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Article Info
doi: 10.1097/HM9.0000000000000194
  • Receive Date：2025-12-07
  • Online Date：2026-06-05
  • Published：2026-03-25
Article Data
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History
  • Received：2025-12-07
  • Accepted：2026-02-16
Funding
Development of a Major Chinese Herbal Medicine Species, Pueraria montana (Lour.). Merr (Pueraria lobata, Puerariae thom-sonii)(2017YFC1702900)
Key R&D Program of Jiangxi Province(20224BBG71023)
National Key R&D Program(2024YFE0104600)
National Administration of Traditional Chinese Medicine Project(GZY-KJS-2023-033)
Affiliations
    1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, China
    2Universidade de Lisboa, Alameda da Universidade, Cidade Universitária, Portugal
    3National Key Laboratory for the Creation of Classic Prescriptions and Modern Traditional Chinese Medicine, Nanchang, China
    4Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Corresponding:

* Corresponding author. Weifeng Zhu, E-mail:
Jiwen Zhang, E-mail:
Yongmei Guan, E-mail: .
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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