Acupoints as state-dependent neuroimmune gateways: insights from stress-responsive neuroimmune circuits

Acupoints as state-dependent neuroimmune gateways: insights from stress-responsive neuroimmune circuits

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Hi-Joon Park¹^,²^,^*

Acupuncture and Herbal Medicine | 2026, 6(2) : 258 - 260

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Acupuncture and Herbal Medicine | 2026, 6(2): 258-260

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Acupoints as state-dependent neuroimmune gateways: insights from stress-responsive neuroimmune circuits

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Hi-Joon Park¹^,²^,^*

Affiliations

¹Systems & Translational Acupuncture Research (STAR) Lab, Acupuncture & Meridian Science Research Center (AMSRC), Kyung Hee University, Seoul, South Korea

²Department of Anatomy and Information Sciences, College of Korean Medicine, Kyung Hee University, Seoul, South Korea

Published: 2026-06-25 doi: 10.1097/HM9.0000000000000197

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Hi-Joon Park. Acupoints as state-dependent neuroimmune gateways: insights from stress-responsive neuroimmune circuits[J]. Acupuncture and Herbal Medicine, 2026 , 6 (2) : 258 -260 . DOI: 10.1097/HM9.0000000000000197

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Funding

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National Research Foundation of Korea funded by the Korean government(RS-2024-00409969)

References

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[1]

Pondeljak N, Lugović-Mihić L. Stress-induced interaction of skin immune cells, hormones, and neurotransmitters. Clin Ther 2020;42(5):757–770.

[2]

Tian J, Cao Y, Li Y, et al. A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation. Science 2026;391(6791):1269–1277.

[3]

Chae Y, Kim HY, Lee HJ, et al. The alteration of pain sensitivity at disease-specific acupuncture points in premenstrual syndrome. J Physiol Sci 2007;57(2):115–119.

[4]

Ben H, Li L, Rong PJ, et al. Observation of pain-sensitive points along the meridians in patients with gastric ulcer or gastritis. Evid Based Complement Alternat Med 2012;2012:130802.

[5]

Rong P, Li S, Ben H, et al. Peripheral and spinal mechanisms of acupoint sensitization phenomenon. Evid Based Complement Alternat Med 2013;2013:742195.

[6]

Tan Y, Wang C, Yin X, et al. Understanding acupoint sensitization: a narrative review on phenomena, potential mechanism, and clinical application. Evid Based Complement Alternat Med 2019;2019:6064358.

[7]

Cui X, Liu K, Gao X, et al. Advancing the understanding of acupoint sensitization and plasticity through cutaneous C-nociceptors. Front Neurosci 2022;16:822436.

[8]

Cui X, Zhang Z, Xi H, et al. Sympathetic-sensory coupling as a potential mechanism for acupoints sensitization. J Pain Res 2023;16:2997–3004.

[9]

Lim DH, Ryu Y, Hahm DH, et al. Acupuncture points can be identified as cutaneous neurogenic inflammatory spots. Sci Rep 2017;7(1):15214.

[10]

Fan Y, Kim DH, Gwak YS, et al. The role of substance P in acupuncture signal transduction and effects. Brain Behav Immun 2021;91:683–694.

[11]

Yi YJ, Kim DH, Chang S, et al. Electroacupuncture at neurogenic spots in referred pain areas attenuates hepatic damages in bile duct-ligated rats. Int J Mol Sci 2021;22(4):1974.

[12]

Liu S, Wang Z, Su Y, et al. Somatotopic organization and intensity dependence in driving distinct NPY-expressing sympathetic pathways by electroacupuncture. Neuron 2020;108(3):436–450.e7.

[13]

Liu S, Wang ZF, Su YS, et al. A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis. Nature 2021;598(7882):641–645.

[14]

Dong S, Zhao L, Liu J, et al. Neuroanatomical organization of electroacupuncture in modulating gastric function in mice and humans. Neuron 2025;113(19):3243–3259.e11.

[15]

Oh JY, Bae SJ, Ji JY, et al. Peripheral mast cell derives the effects of acupuncture in Parkinson’s disease. Front Aging Neurosci 2024;16:1376756.

[16]

Oh JY, Lee H, Jang SY, et al. Central role of hypothalamic circuits for acupuncture’s anti-Parkinsonian effects. Adv Sci (Weinh) 2024;11(43):e2403245.

Appendix

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Year 2026 volume 6 Issue 2

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Article Info

doi: 10.1097/HM9.0000000000000197

Receive Date：2026-03-30
Online Date：2026-11-04
Published：2026-06-25

Article Data

Affiliations

History

Received：2026-03-30
Accepted：2026-04-02

Funding

National Research Foundation of Korea funded by the Korean government(RS-2024-00409969)

Affiliations

¹Systems & Translational Acupuncture Research (STAR) Lab, Acupuncture & Meridian Science Research Center (AMSRC), Kyung Hee University, Seoul, South Korea

²Department of Anatomy and Information Sciences, College of Korean Medicine, Kyung Hee University, Seoul, South Korea

Corresponding:

^* Hi-Joon Park, E-mail: acufind@khu.ac.kr.

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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