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Poria cocos (Fu Ling), a traditional medicinal fungus with more than two millennia of documented use, occupies a central role in East Asian medical practice. This review systematically examines its historical development as recorded in classical materia medica, emphasizing the evolution of its medicinal sources and the specific fungal parts employed. The representative chemical constituents - namely triterpenoids and polysaccharides - are thoroughly summarized with regard to their structural types and distinguishing characteristics. Building on classical therapeutic indications such as promoting diuresis, strengthening the spleen, and calming the mind, recent research is reviewed to elucidate the expanded pharmacological profile of P. cocos. A particular focus is given to its antitumor effects, immunomodulatory activity, anti-obesity properties, mitigation of metabolic dysfunction-associated steatotic liver disease, and enhancement of intestinal barrier function. Current mainstream quality evaluation methodologies are outlined, followed by an in-depth discussion of the pharmacokinetics of its principal bioactive components, with special emphasis on the microbial fermentation of polysaccharides into short-chain fatty acids by the gut microbiota. The synergistic role of P. cocos in polyherbal formulations, exemplified by Sijunzi Decoction, is analyzed to highlight its compatibility-enhancing effects. Contemporary applications in modern pharmaceuticals and functional foods are also summarized. Finally, key challenges and prospective directions for future research and industrial development are addressed. This review aimed to provide a comprehensive reference for basic research, product innovation, and clinical utilization of P. cocos.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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