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Research progress on the hepatoprotective effect, pharmacokinetic properties, and hepatotoxicity of geniposide
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Songyuan Tang1, Guangli Yan1, Ling Kong1, Hui Sun1, *, Chang Liu1, Ying Han1, Xijun Wang1, 2, *
Acupuncture and Herbal Medicine | 2025, 5(2) : 136 - 146
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Acupuncture and Herbal Medicine | 2025, 5(2): 136-146
• Review Articles •
Research progress on the hepatoprotective effect, pharmacokinetic properties, and hepatotoxicity of geniposide
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Songyuan Tang1, Guangli Yan1, Ling Kong1, Hui Sun1, *, Chang Liu1, Ying Han1, Xijun Wang1, 2, *
Affiliations
  • 1State Key Laboratory of Integration and Innovation of Classical Formula and Modern Chinese Medicines, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China
  • 2State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau.
Published: 2025-06-25 doi: 10.1097/HM9.0000000000000160
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Liver disease (LD) is a global health problem caused by multiple factors. At present, there are still obvious problems with limited efficacy and strong side effects of drugs used in the clinical treatment of LD. Therefore, it is of great significance to search for effective hepatoprotective drugs from natural products. Geniposide (GS) is a cyclic ether terpenoid compound and a key component in the traditional Chinese medicine Gardenia jasminoides. It has a significant inhibitory effect on LD. However, there is currently no literature systematically analyzing its mechanism of action. To adapt to the environment of new drug research and the need for precision medication, this article summarizes the pathways and possible mechanisms of action discovered by GS in the treatment of LD, based on recent research literature: regulating bile stasis, antioxidant and anti-apoptosis, improving amino acid metabolism, improving energy metabolism, regulating lipid metabolism, anti-inflammatory and analgesic effects, etc. It also summarizes the pharmacokinetics of GS in vivo and discusses the liver toxicity of GS that is positively correlated with dosage. In addition, the existing problems in current research and possible future development directions were also discussed, to lay the foundation for the clinical development of natural product GS.

Geniposide  /  Hepatotoxicity  /  Liver disease  /  Molecular mechanism  /  Pharmacokinetics
Songyuan Tang, Guangli Yan, Ling Kong, Hui Sun, Chang Liu, Ying Han, Xijun Wang. Research progress on the hepatoprotective effect, pharmacokinetic properties, and hepatotoxicity of geniposide[J]. Acupuncture and Herbal Medicine, 2025 , 5 (2) : 136 -146 . DOI: 10.1097/HM9.0000000000000160
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Funding
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  • National Natural Science Foundation of China Key Project(81830110)
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Year 2025 volume 5 Issue 2
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Article Info
doi: 10.1097/HM9.0000000000000160
  • Receive Date：2025-01-10
  • Online Date：2026-11-04
  • Published：2025-06-25
Article Data
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History
  • Received：2025-01-10
  • Accepted：2025-05-14
Funding
National Natural Science Foundation of China Key Project(81830110)
Affiliations
    1State Key Laboratory of Integration and Innovation of Classical Formula and Modern Chinese Medicines, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China
    2State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau.

Corresponding:

* Hui Sun, E-mail: ;
Xijun Wang, E-mail: .
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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