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Article(id=1322906936332657395, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322887411688919265, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1618848000000, acceptedDateStr=2021-04-20, onlineDate=1793335192043, onlineDateStr=2026-10-30, pubDate=1636905600000, pubDateStr=2021-11-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793335192043, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793335192043, creator=13701087609, updateTime=1793335192043, updator=13701087609, issue=Issue{id=1322887411688919265, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='21', pageStart='1921', pageEnd='2016', issueExtLink='null', onlineDate='null', pubDate='1636905600000', pubDateStr='2021-11-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793330537006, creator='13701087609', updateTime=1793337443794, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322916380919608076, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322887411688919265, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322916380919608077, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322887411688919265, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1982, endPage=1989, ext={EN=ArticleExt(id=1322906936508818164, articleId=1322906936332657395, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress for controlled release mechanism of smart drug carrier, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Smart drug carriers with a unique stimulus-response mechanism can respond to changes in physical and chemical properties under the stimulation of exogenous or human body's own environmental factors, and thus can control the delivery site of the drug, and automatically adjust the drug release rate. Currently, it has become one of the research hotspots in the field of materials science and pharmacy. Due to the advantages of improving the bioavailability of drugs in the body and reducing their side effects, smart drug carriers will play an increasingly important role in future clinical treatments. This article reviews the latest research progress in the mechanism of action, material properties and potential applications of stimulus-responsive smart drug carriers for different stimuli, and further prospects for their development.

, authors=Yue-yue FAN1, 2, Wen-yan HAO2, Sha-sha ZHANG3, Yang YANG2, Chun-sheng GAO1, 2, authorsList=Yue-yue FAN, Wen-yan HAO, Sha-sha ZHANG, Yang YANG, Chun-sheng GAO, authorCompany=null, correspAuthors=Yang YANG, Chun-sheng GAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322906936743699189, articleId=1322906936332657395, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=“智能型”药物载体调释新机制研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

具有独特刺激-响应机制的“智能型”药物载体，可在外源型或人体自身环境因素的刺激下做出相关理化性质改变的响应调节，控制药物到达靶部位，并且能自动调节释药速率，已成为当前材料学与药剂学领域的研究热点之一。由于具有提高药物在体内的生物利用度和降低其毒副作用等优点，“智能型”药物载体将在未来的临床治疗中起到越来越重要的作用。本文综述了面向不同刺激因素的刺激响应型智能药物载体的作用机制、材料性质特点和潜在应用的最新研究进展，并对其发展前景进行进一步的展望。

, authors=范月月1, 2, 郝文艳2, 张沙莎3, 杨阳2, 高春生1, 2, authorsList=范月月, 郝文艳, 张沙莎, 杨阳, 高春生, authorCompany=null, correspAuthors=杨阳, 高春生, authorNote=

郝文艳，女，博士研究生，主要从事仿生药物递送系统研究。联系电话：（010）66931638，E-mail：。

范月月，女，硕士研究生，主要从事主动靶向制剂技术研究。联系电话：（010）66931638，E-mail：。

, correspAuthorsNote=
杨阳，男，副研究员，主要从事仿生药物递送系统研究。联系电话：（010）66931638，E-mail：。
高春生，男，研究员，主要从事控释与个体化制剂技术研究。联系电话：（010）66931638，E-mail：。
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范月月，女，硕士研究生，主要从事主动靶向制剂技术研究。联系电话：（010）66931638，E-mail：。

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范月月，女，硕士研究生，主要从事主动靶向制剂技术研究。联系电话：（010）66931638，E-mail：。

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“智能型”药物载体调释新机制研究进展
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范月月 1, 2 , 郝文艳 2 , 张沙莎 3 , 杨阳 2 , 高春生 1, 2
中国新药杂志 | 综述 2021,30(21): 1982-1989
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中国新药杂志 |综述 2021 , 30 (21) : 1982 -1989
“智能型”药物载体调释新机制研究进展
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2军事医学研究院毒物药物研究所，北京　100850, bio={"content":"

范月月，女，硕士研究生，主要从事主动靶向制剂技术研究。联系电话：（010）66931638，E-mail：。

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范月月，女，硕士研究生，主要从事主动靶向制剂技术研究。联系电话：（010）66931638，E-mail：。

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范月月1, 2 , 郝文艳2 , 张沙莎3, 杨阳2 , 高春生1, 2
作者信息
  • 1河南大学药学院，开封　475000
  • 2军事医学研究院毒物药物研究所，北京　100850
  • 3佳木斯大学附属第一医院，佳木斯　154003
通讯作者:
杨阳，男，副研究员，主要从事仿生药物递送系统研究。联系电话：（010）66931638，E-mail：。
高春生，男，研究员，主要从事控释与个体化制剂技术研究。联系电话：（010）66931638，E-mail：。
作者简介:

郝文艳，女，博士研究生，主要从事仿生药物递送系统研究。联系电话：（010）66931638，E-mail：。

范月月，女，硕士研究生，主要从事主动靶向制剂技术研究。联系电话：（010）66931638，E-mail：。

Research progress for controlled release mechanism of smart drug carrier
Yue-yue FAN1, 2 , Wen-yan HAO2 , Sha-sha ZHANG3, Yang YANG2 , Chun-sheng GAO1, 2
Affiliations
  • 1College of Pharmacy, Henan University, Kaifeng 475000, China
  • 2Department of Pharmaceutics, Institute of Pharmacology and Toxicology of the Academy of Military Medical Sciences, Beijing 100850, China
  • 3The First Affiliated Hospital of Jiamusi University, Jiamusi 154003, China
出版时间: 2021-11-15
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具有独特刺激-响应机制的“智能型”药物载体，可在外源型或人体自身环境因素的刺激下做出相关理化性质改变的响应调节，控制药物到达靶部位，并且能自动调节释药速率，已成为当前材料学与药剂学领域的研究热点之一。由于具有提高药物在体内的生物利用度和降低其毒副作用等优点，“智能型”药物载体将在未来的临床治疗中起到越来越重要的作用。本文综述了面向不同刺激因素的刺激响应型智能药物载体的作用机制、材料性质特点和潜在应用的最新研究进展，并对其发展前景进行进一步的展望。

“智能型”药物递送系统  /  “智能型”药物载体  /  药物释放刺激  /  刺激响应机制  /  调释机制

Smart drug carriers with a unique stimulus-response mechanism can respond to changes in physical and chemical properties under the stimulation of exogenous or human body's own environmental factors, and thus can control the delivery site of the drug, and automatically adjust the drug release rate. Currently, it has become one of the research hotspots in the field of materials science and pharmacy. Due to the advantages of improving the bioavailability of drugs in the body and reducing their side effects, smart drug carriers will play an increasingly important role in future clinical treatments. This article reviews the latest research progress in the mechanism of action, material properties and potential applications of stimulus-responsive smart drug carriers for different stimuli, and further prospects for their development.

smart drug delivery systems  /  smart drug carrier  /  drug release stimulus  /  stimulus response mechanism  /  controlled release mechanism
范月月, 郝文艳, 张沙莎, 杨阳, 高春生. “智能型”药物载体调释新机制研究进展. 中国新药杂志, 2021 , 30 (21) : 1982 -1989 .
Yue-yue FAN, Wen-yan HAO, Sha-sha ZHANG, Yang YANG, Chun-sheng GAO. Research progress for controlled release mechanism of smart drug carrier[J]. Chinese Journal of New Drugs, 2021 , 30 (21) : 1982 -1989 .
基金
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  • 国家自然科学基金资助项目(82073783)
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2021年第30卷第21期
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  • 首发时间：2026-10-30
  • 出版时间：2021-11-15
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  • 录用日期：2021-04-20
基金
国家自然科学基金资助项目(82073783)
作者信息
    1河南大学药学院，开封　475000
    2军事医学研究院毒物药物研究所，北京　100850
    3佳木斯大学附属第一医院，佳木斯　154003

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杨阳，男，副研究员，主要从事仿生药物递送系统研究。联系电话：（010）66931638，E-mail：。
高春生，男，研究员，主要从事控释与个体化制剂技术研究。联系电话：（010）66931638，E-mail：。
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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