Article(id=1322906910504124822, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322906824709648449, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1631116800000, acceptedDateStr=2021-09-09, onlineDate=1793335185886, onlineDateStr=2026-10-30, pubDate=1635523200000, pubDateStr=2021-10-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793335185886, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793335185886, creator=13701087609, updateTime=1793335185886, updator=13701087609, issue=Issue{id=1322906824709648449, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='20', pageStart='1825', pageEnd='1920', issueExtLink='null', onlineDate='null', pubDate='1635523200000', pubDateStr='2021-10-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793335165428, creator='13701087609', updateTime=1793337419278, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322916278284976934, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322906824709648449, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322916278284976935, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322906824709648449, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1890, endPage=1895, ext={EN=ArticleExt(id=1322906911221350807, articleId=1322906910504124822, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Comparison of membrane separation method and alcohol precipitation method as purification process of Weixuening mixture, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To evaluate the purification process of Weixuening mixture extract by alcohol precipitation method and membrane separation method.
Methods: In this study, the Weixuening mixture extract was used as the research object, and physicochemical parameters, solid removal rate, and the transfer rates of indicative components were used as the indexes to evaluate the two different refining processes of Weixuening mixture extract, i.e., alcohol precipitation method and membrane separation method. By investigating the influences of different molecular weight cut-offs, operating pressure, and extracting solution concentration on membrane separation index and membrane flux, the best purification process was selected.
Results: The physicochemical parameters of the membrane separation method were significantly better than those of the alcohol precipitation method. The transfer rates of the indicative components of the alcohol precipitation solution such as catechin, epicatechin, polydatin, resveratrol, and quercetin, respectively, were 82.34%, 83.31%, 79.06%, 77.51%, and 80.16%, respectively. The solid removal rate was 64.75%. The best process for membrane separation was as follows: the membrane pressure was 0.5 MPa; the extract concentration was 0.11 g·mL-1; the molecular weight cutoff was 30 kDa. The transfer rates of the indicative components such as catechin, epicatechin, polydatin, resveratrol, and quercetin in the membrane separated solution were 83.44%, 84.32%, 80.42%, 83.36%, and 83.58%, respectively. The membrane flux was 10.57 mL·m-2·min-1 and the solid removal rate was 65.96%.
Conclusion: Compared with the alcohol precipitation method, the membrane separation method is more conducive to the refining of the extract of Weixuening mixture, which lays the foundation for the industrial production of Weixuening mixture.
, authors=Tai-wei DONG, Jun-bo ZOU, Xiao-fei ZHANG, Jing-yuan WANG, Ya-jun SHI, Jing SUN, authorsList=Tai-wei DONG, Jun-bo ZOU, Xiao-fei ZHANG, Jing-yuan WANG, Ya-jun SHI, Jing SUN, authorCompany=null, correspAuthors=Ya-jun SHI, Jing SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322906913805042072, articleId=1322906910504124822, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=基于膜分离法与醇沉法维血宁合剂工艺研究对比, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 评价维血宁合剂提取液醇沉法和膜分离法的精制工艺。
方法： 本研究以维血宁合剂提取液为研究对象，以物理化学参数、固形物去除率、指标性成分转移率为指标，评价维血宁合剂提取液醇沉法和膜分离法2种不同的精制工艺，通过考察不同截留分子量、操作压力、提取液浓度对膜分离指标以及膜通量的影响，优选最佳的纯化工艺。
结果： 膜分离法的物理化学参数优于醇沉法。醇沉液指标性成分儿茶素、表儿茶素、虎杖苷、白藜芦醇、槲皮素的转移率分别为82.34%，83.31%，79.06%，77.51%，80.16%，固形物去除率为64.75%。优选膜分离最佳工艺为膜压力0.5 MPa；提取液浓度0.11 g·mL-1；截留分子量大小30 kDa，膜分离液指标性成分儿茶素、表儿茶素、虎杖苷、白藜芦醇、槲皮素的转移率分别为83.44%，84.32%，80.42%，83.36%，83.58%，膜通量为10.57 mL·m-2·min-1，固形物去除率为65.96%。
结论： 相比于醇沉法，膜分离法更有利于维血宁合剂提取液的精制，为维血宁合剂工业化生产奠定基础。
, authors=董泰玮, 邹俊波, 张小飞, 王景媛, 史亚军, 孙静, authorsList=董泰玮, 邹俊波, 张小飞, 王景媛, 史亚军, 孙静, authorCompany=null, correspAuthors=史亚军, 孙静, authorNote=
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=rkZvJaGGbUlWfWlhFph+6Q==, magXml=WYffTpog5dOZSe7LRIBc4Q==, pdfUrl=null, pdf=f7SWmJn/DhpnfNLsU/KK/Q==, pdfFileSize=978090, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=sOHp7mmAQUrP9DPU9RXqzg==, mapNumber=null, fund=null)}, authors=[Author(id=1322906914983641502, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1484904430@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322906915063333280, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906914983641502, language=EN, stringName=Tai-wei DONG, firstName=Tai-wei, middleName=null, lastName=DONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322906915147219361, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906914983641502, language=CN, stringName=董泰玮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=陕西中医药大学药学院，西安 712046, bio={"content":"
董泰玮，男，博士，讲师，主要从事中药新剂型与新技术研究。E-mail：1484904430@qq.com。
"}, bioImg=null, bioContent=
董泰玮，男，博士，讲师，主要从事中药新剂型与新技术研究。E-mail：1484904430@qq.com。
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322906914723594650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, xref=null, ext=[AuthorCompanyExt(id=1322906914731983259, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1322906914740371868, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=陕西中医药大学药学院，西安 712046)])]), Author(id=1322906915235299747, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322906915398877605, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906915235299747, language=EN, stringName=Jun-bo ZOU, firstName=Jun-bo, middleName=null, lastName=ZOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322906915478569382, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906915235299747, language=CN, stringName=邹俊波, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=陕西中医药大学药学院，西安 712046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322906914723594650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, xref=null, ext=[AuthorCompanyExt(id=1322906914731983259, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1322906914740371868, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=陕西中医药大学药学院，西安 712046)])]), Author(id=1322906915579232680, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322906915654730154, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906915579232680, language=EN, stringName=Xiao-fei ZHANG, firstName=Xiao-fei, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322906917315674539, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906915579232680, language=CN, stringName=张小飞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=陕西中医药大学药学院，西安 712046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322906914723594650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, xref=null, ext=[AuthorCompanyExt(id=1322906914731983259, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1322906914740371868, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=陕西中医药大学药学院，西安 712046)])]), Author(id=1322906917395366317, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322906917470863791, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906917395366317, language=EN, stringName=Jing-yuan WANG, firstName=Jing-yuan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322906917546361264, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906917395366317, language=CN, stringName=王景媛, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=陕西中医药大学药学院，西安 712046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322906914723594650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, xref=null, ext=[AuthorCompanyExt(id=1322906914731983259, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1322906914740371868, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=陕西中医药大学药学院，西安 712046)])]), Author(id=1322906917630247346, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=2051004@sntcm.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322906917705744820, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906917630247346, language=EN, stringName=Ya-jun SHI, firstName=Ya-jun, middleName=null, lastName=SHI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322906917869322677, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906917630247346, language=CN, stringName=史亚军, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=陕西中医药大学药学院，西安 712046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322906914723594650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, xref=null, ext=[AuthorCompanyExt(id=1322906914731983259, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1322906914740371868, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=陕西中医药大学药学院，西安 712046)])]), Author(id=1322906917944820151, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=ph.175@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322906918028706233, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906917944820151, language=EN, stringName=Jing SUN, firstName=Jing, middleName=null, lastName=SUN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322906918280364474, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, authorId=1322906917944820151, language=CN, stringName=孙静, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=陕西中医药大学药学院，西安 712046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322906914723594650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, xref=null, ext=[AuthorCompanyExt(id=1322906914731983259, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1322906914740371868, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=陕西中医药大学药学院，西安 712046)])])], keywords=[Keyword(id=1322906918393610683, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, language=EN, orderNo=1, keyword=Weixuening mixture), Keyword(id=1322906918469108156, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, language=EN, orderNo=2, keyword=membrane separation), Keyword(id=1322906918708183486, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, language=EN, orderNo=3, keyword=alcohol precipitation), Keyword(id=1322906918783680959, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, language=EN, orderNo=4, keyword=purification process), Keyword(id=1322906918867567040, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, language=EN, orderNo=5, keyword=transfer rate), Keyword(id=1322906918959841729, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, language=CN, orderNo=1, keyword=维血宁合剂), Keyword(id=1322906919144391106, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, language=CN, orderNo=2, keyword=膜分离法), Keyword(id=1322906919224082883, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, language=CN, orderNo=3, keyword=醇沉法), Keyword(id=1322906919295386052, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, language=CN, orderNo=4, keyword=纯化工艺), Keyword(id=1322906919375077829, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, language=CN, orderNo=5, keyword=转移率)], refs=[Reference(id=1322906919823868364, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=许洪波, 唐志书, 刘妍如, 等. 基于网络药理学方法预测维血宁合剂防治新型冠状病毒肺炎的活性成分及潜在靶点[J/OL]. 中药材, 2020, 43(10): 2602-2609., articleTitle=null, refAbstract=null), Reference(id=1322906919890977229, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=袁武会. 维血宁合剂的灭菌工艺研究[J]. 西北药学杂志, 2012, 27(6): 563-565., articleTitle=null, refAbstract=null), Reference(id=1322906919962280398, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=黄妙儿, 马永华, 黄云平, 等. 维血宁治疗急性髓性白血病化疗后血小板减少临床观察[J]. 深圳中西医结合杂志, 2017, 27(3): 43-44., articleTitle=null, refAbstract=null), Reference(id=1322906920050360783, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=唐进法, 张辉, 张娜娜, 等. 膜分离法和醇沉法对清消口服液的纯化效果比较[J]. 中国实验方剂学杂志, 2014, 20(8): 28-30., articleTitle=null, refAbstract=null), Reference(id=1322906920125858256, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=徐春伟, 李梅生, 周守勇, 等. 聚乳酸分离膜的制备及其改性研究进展[J/OL]. 化工新型材料.[2021-06-24]. http://kns.cnki.net/kcms/detail/11.2357.TQ.20210512.1319.313.html., articleTitle=null, refAbstract=null), Reference(id=1322906920188772817, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=赵晴, 何少剑, 林俊, 等. 基于共混聚醚共聚酰胺的气体分离膜的制备及性能研究[J]. 中国塑料, 2019, 33(9): 13-20., articleTitle=null, refAbstract=null), Reference(id=1322906922063626706, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=杨磊, 朱华旭, 唐志书, 等. 不同分离精制工艺对中药复方骨痹颗粒喷干粉制剂学性质影响[J]. 中草药, 2017, 48(16): 3308-3312., articleTitle=null, refAbstract=null), Reference(id=1322906922164290003, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=徐思宁. 膜分离技术替代中药醇沉工艺适宜性的初步研究[D]. 陕西中医药大学, 2020., articleTitle=null, refAbstract=null), Reference(id=1322906922243981780, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=汪荔, 王征, 张娇, 等. 传统工艺与膜分离技术联合对马齿苋多糖的提取分离与抗氧化活性研究[J]. 中草药, 2016, 47(10): 1676-1681., articleTitle=null, refAbstract=null), Reference(id=1322906922336256469, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=陈雪婷, 徐文杰, 李洁环. 膜分离技术在布渣叶黄酮类化合物提取中的应用[J]. 应用海洋学学报, 2020, 36(2): 143-144., articleTitle=null, refAbstract=null), Reference(id=1322906922466279894, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=null, journalName=null, refType=null, unstructuredReference=冯敬文, 黄桂芬, 江建航, 等. 膜分离技术在金边土鳖活性成分分离中的应用[J]. 中国处方药, 2020, 18(7): 34-36., articleTitle=null, refAbstract=null), Reference(id=1322906922558554583, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=null, journalName=null, refType=null, unstructuredReference=宋逍, 段玺, 赵鹏, 等. 膜分离技术应用于柴黄口服液的纯化分离工艺研究[J]. 吉林中医药, 2017, 37(2): 183-187., articleTitle=null, refAbstract=null), Reference(id=1322906922659217880, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=null, journalName=null, refType=null, unstructuredReference=董洁, 方玉婷, 郭立玮. 不同提取分离方法对芍药甘草汤物质组成影响的初步研究[J]. 中成药, 2010, 32(12): 2170-2172., articleTitle=null, refAbstract=null), Reference(id=1322906922726326745, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=null, journalName=null, refType=null, unstructuredReference=秦枫, 李金贵, 朱善元, 等. 响应面法优ZTC1+1Ⅱ型澄清剂对三七茎叶皂苷提取液的除杂工艺[J]. 湖北农业科学, 2020, 59(20): 150-154, 169., articleTitle=null, refAbstract=null), Reference(id=1322906922915070426, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=null, journalName=null, refType=null, unstructuredReference=孙久义. 我国膜分离技术综述[J]. 当代化工研究, 2019(2): 27-28., articleTitle=null, refAbstract=null), Reference(id=1322906922990567899, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=null, journalName=null, refType=null, unstructuredReference=杨磊, 朱华旭, 唐志书, 等. 不同分离精制工艺对中药复方骨痹颗粒喷干粉制剂学性质影响[J]. 中草药, 2017, 48(16): 3308-3312., articleTitle=null, refAbstract=null), Reference(id=1322906923074453980, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=null, journalName=null, refType=null, unstructuredReference=曹林林, 田正良, 宋宗良, 等. 维血宁合剂治疗抗甲状腺药物导致白细胞减少症临床观察[J]. 时珍国医国药, 2011, 22(8): 1971., articleTitle=null, refAbstract=null)], funds=[Fund(id=1322906919467352519, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, awardId=82104412, language=CN, fundingSource=国家自然科学基金资助项目(82104412), fundOrder=null, country=null), Fund(id=1322906919530267080, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, awardId=2020JQ-865, language=CN, fundingSource=陕西省自然科学基础研究项目(2020JQ-865), fundOrder=null, country=null), Fund(id=1322906919588987337, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, awardId=20JK0597, language=CN, fundingSource=陕西省教育厅科研项目(20JK0597), fundOrder=null, country=null), Fund(id=1322906919664484810, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, awardId=2019K01-19, language=CN, fundingSource=2019咸阳重大科技专项计划基金资助项目(2019K01-19), fundOrder=null, country=null), Fund(id=1322906919723205067, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, awardId=2019-YL11, language=CN, fundingSource=陕西中医药大学学科创新团队项目(2019-YL11), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322906914723594650, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, xref=null, ext=[AuthorCompanyExt(id=1322906914731983259, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1322906914740371868, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322906910504124822, companyId=1322906914723594650, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=陕西中医药大学药学院，西安 712046)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2021/V30/I20/1890, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2021/V30/I20/1890, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2021/V30/I20/1890, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2021/V30/I20/1890, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1635523200000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
5
0
关闭全屏
北京市海淀区学院南路86号
010-62662699（运营及技术支持）
qkjq@cast.org.cn
