中国新药杂志

盐酸克林霉素棕榈酸酯分散片治疗慢性牙周炎的有效性与安全性

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张静 ¹ , 郑晶晶 ² , 吴英 ³ , 吴敏 ⁴

中国新药杂志 | 临床研究 2021,30(20): 1867-1870

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中国新药杂志 |临床研究 2021 , 30 (20) : 1867 -1870

盐酸克林霉素棕榈酸酯分散片治疗慢性牙周炎的有效性与安全性

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张静¹, 郑晶晶², 吴英³, 吴敏⁴

作者信息

¹上海市第八人民医院，上海　200235

²漯河市第二人民医院，漯河　462000

³上海市口腔病防治医院，上海　201112

⁴复旦大学附属中山医院，上海　200031

作者简介:

张静，女，硕士研究生，初级医师，主要从事口腔病诊疗研究。E-mail：zhangjing7303@126.com。

Efficacy and safety of clindamycin hydrochloride palmitate dispersion tablets for treatment of chronic periodontitis

Jing ZHANG¹, Jing-jing ZHENG², Ying WU³, Min WU⁴

Affiliations

¹The Eighth People's Hospital of Shanghai, Shanghai 200235, China

²Luohe Second People's Hospital, Luohe 462000, China

³Shanghai Stomatological Hospital, Shanghai 201112, China

⁴Zhongshan Hospital of Fudan University, Shanghai 200031, China

出版时间: 2021-10-30

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摘要

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目的：

评价盐酸克林霉素棕榈酸酯分散片治疗慢性牙周炎的有效性与安全性。

方法：

试验选取2020年5月—2021年5月于我院诊断为慢性牙周炎的患者150例，随机分为观察组和对照组，每组各75例。经牙周基础治疗后，分别给予盐酸克林霉素棕榈酸酯分散片或头孢克洛缓释胶囊联合甲硝唑片治疗1周。观察和比较两组牙周指标，如探诊出血（BOP）、出血指数（BI）、牙周探诊深度（PD）和附着水平（AL）以及总有效率、不良事件发生率和患者依从性。

结果：

与对照组相比，观察组治疗后BOP和BI显著减少（P<0.01），PD和AL比较无差异（P>0.05）；观察组治疗总有效率略低于対照组，但比较差异无统计学意义（P>0.05）；观察组不良事件发生率低于対照组，患者依从性良好。

结论：

盐酸克林霉素棕榈酸酯分散片治疗慢性牙周炎疗效明显，不良事件发生率低，安全性和患者依从性良好。

关键词

慢性牙周炎 / 盐酸克林霉素棕榈酸酯分散片 / 头孢克洛缓释胶囊 / 甲硝唑片

Abstract

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Objective:

To observe the efficacy and safety of clindamycin hydrochloride palmitate dispersion tablets for the treatment of chronic periodontitis.

Methods:

One hundred and fifty patients diagnosed with chronic periodontitis in our hospital from May 2020 to May 2021 were randomly divided into observation group (75 cases) and control group (75 cases). After the initial therapy of periodontal diseases, the two groups were administered with clindamycin hydrochloride palmitate dispersion tablets or cefaclor sustained-release capsules combined with metronidazole tablets for one week, respectively. Periodontal indexes, such as bleeding on probing (BOP), bleeding index (BI), periodontal probe depth (PD) and adhesion level (AL), as well as the total effective rate, incidence of adverse events and patient compliance, were observed and compared between the two groups.

Results:

Compared with the control group, the incidences of BOP and BI were significantly lower in the observation group after treatment (P<0.01), but PD and AL had no significant difference (P>0.05). The total effective rate of treatment in the observation group was lower than that of the control group, but the difference was not statistically significant (P>0.05). The incidence of adverse events in the observation group was lower than the control group and the patients had good compliance.

Conclusion:

Clindamycin hydrochloride palmitate dispersion tablets was effective in the treatment of chronic periodontitis, with low incidence of adverse events, good safety and patient compliance.

Key words

chronic periodontitis / clindamycin hydrochloride palmitate dispersion tablets / cefaclor sustained-release capsules / metronidazole tablets

引用本文

张静, 郑晶晶, 吴英, 吴敏. 盐酸克林霉素棕榈酸酯分散片治疗慢性牙周炎的有效性与安全性. 中国新药杂志, 2021 , 30 (20) : 1867 -1870 .

Jing ZHANG, Jing-jing ZHENG, Ying WU, Min WU. Efficacy and safety of clindamycin hydrochloride palmitate dispersion tablets for treatment of chronic periodontitis[J]. Chinese Journal of New Drugs, 2021 , 30 (20) : 1867 -1870 .

参考文献

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2021年第30卷第20期

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首发时间：2026-10-30
出版时间：2021-10-30

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¹上海市第八人民医院，上海　200235

²漯河市第二人民医院，漯河　462000

³上海市口腔病防治医院，上海　201112

⁴复旦大学附属中山医院，上海　200031

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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