Article(id=1322906841440727228, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322906824709648449, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1632240000000, acceptedDateStr=2021-09-22, onlineDate=1793335169419, onlineDateStr=2026-10-30, pubDate=1635523200000, pubDateStr=2021-10-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793335169419, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793335169419, creator=13701087609, updateTime=1793335169419, updator=13701087609, issue=Issue{id=1322906824709648449, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='20', pageStart='1825', pageEnd='1920', issueExtLink='null', onlineDate='null', pubDate='1635523200000', pubDateStr='2021-10-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793335165428, creator='13701087609', updateTime=1793337419278, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322916278284976934, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322906824709648449, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322916278284976935, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322906824709648449, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1850, endPage=1854, ext={EN=ArticleExt(id=1322906841621082301, articleId=1322906841440727228, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Infection titer detection of Sendai virus vector by flow cytometry, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To establish a rapid, convenient and robust method for detecting the infection titer of Sendai virus (Sev) vectors.
Methods: With transmission-defective Sendai virus vector as the research target and flow cytometry as the detection method, a mathematic model based on Poisson's distribution was established, and the infection titer was determined by one parameter of the mathematic model after curve-fitting.
Results: An innovative method for detecting the infection titer of Sendai virus vector was successfully established. There were no significant differences between the results obtained from the flow cytometry method and traditional immunofluorescence method, and the flow cytometry method displayed good reproducibility [infection titer is (2.13±0.05)×109 IU·mL-1, RSD is 2.34%].
Conclusion: The infection titer detection is an important quality control item of viral vector gene therapy products and the traditional methods such as plaque method, TCID50 method and immunofluorescence method have the disadvantages of long experiment cycle, bad reproducibility and poor objectivity. This study is of significance to be a representative quality control reference for infection titer detecting of other viral vectors.
, authors=Zhi-hao FU, Jun-zhi WANG, authorsList=Zhi-hao FU, Jun-zhi WANG, authorCompany=null, correspAuthors=Jun-zhi WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322906841985986750, articleId=1322906841440727228, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=应用流式细胞术检测仙台病毒载体感染滴度, columnId=1236330552693944345, journalTitle=中国新药杂志, columnName=生物医药前沿, runingTitle=null, highlight=null, articleAbstract=
目的： 建立一种快速、简便和稳健的用于检测仙台病毒载体感染滴度的方法。
方法： 以传播缺陷型仙台病毒载体为研究对象，流式细胞术为检测方法，建立以泊松分布为基础的数学模型做曲线拟合，以函数中的一项参数做感染滴度的结果判定。
结果： 成功建立了流式细胞术检测仙台病毒载体感染滴度的新方法。与传统的免疫荧光法比较，检测结果无显著性差异，且新方法具有更好的重现性，感染滴度为（2.13±0.05）×109 IU·mL-1，相对标准偏差（RSD）为2.34%。
结论： 病毒载体类基因治疗产品的感染滴度是该类制品的一项重要质控指标。传统的测定方法，如噬斑法、组织半数感染量（TCID50）法和免疫荧光法，实验周期长、重现性差，而且结果判定受主观因素影响。本研究建立了一种适合传播缺陷型仙台病毒载体感染滴度测定的新方法，也可为其他类型病毒载体感染滴度的测定方法研究提供参考。
, authors=付志浩, 王军志, authorsList=付志浩, 王军志, authorCompany=null, correspAuthors=王军志, authorNote=
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付志浩，男，副研究员，主要从事生物技术药质量控制研究。E-mail：fuzhihao@nifdc.org.cn。
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付志浩，男，副研究员，主要从事生物技术药质量控制研究。E-mail：fuzhihao@nifdc.org.cn。
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