Article(id=1322906772440228413, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322887634511314961, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1614096000000, acceptedDateStr=2021-02-24, onlineDate=1793335152968, onlineDateStr=2026-10-30, pubDate=1632931200000, pubDateStr=2021-09-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793335152968, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793335152968, creator=13701087609, updateTime=1793335152968, updator=13701087609, issue=Issue{id=1322887634511314961, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='18', pageStart='1633', pageEnd='1728', issueExtLink='null', onlineDate='null', pubDate='1632931200000', pubDateStr='2021-09-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793330590131, creator='13701087609', updateTime=1793337355310, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322916009916629692, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322887634511314961, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322916009916629693, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322887634511314961, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1703, endPage=1708, ext={EN=ArticleExt(id=1322906772612194878, articleId=1322906772440228413, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Pharmacokinetic investigation of berberine dernivative WZX20 in rats, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To study the pharmacokinetics of berberine dernivative WZX20 in rats.
Methods: SD rats were intragastrically (ig) or intravenously (iv) given WZX20, and plasma were collected after injection. WZX20 components in plasma were determined by LC-MS. Pharmacokinetic parameters were determined from the plasma concentration-time data with DAS software package.
Results: The pharmacokinetic parameters after gastric lavage were as follows: AUC0→t (596.46±22.22) ng·h·mL-1; AUC0-∞ (607.59±23.51) ng·h·mL-1; t1/2 (1.76±0.15) h; CL (32.96±1.3) L·h·kg-1; Vd (83.62±7.54) L·kg-1; Cmax (172.98±13.51) ng·mL-1; Tmax (0.5) h; F=33.19%. The intravenous pharmacokinetics parameters were as follows: AUC0→t (177.61±30.52) ng·h·mL-1; AUC0→∞(183.08±30.90) ng·h·mL-1; t1/2 (1.74±0.17) h; CL (11.23±2.18) L·h·kg-1; Vd (25.17±6.81) L·kg-1.
Conclusion: The established LC-Ms method is accurate, sensitive and rapid, and can be used for the blood concentration determination of WZX20. The pharmacokinetic parameters of WZX20 provide a good foundation for the study on the druggability of WZX20.
, authors=Gao-feng ZHU
1, 2, Rui CHEN
2, Yi-ming ZHANG
3, Kai-hong ZHU
3, Jian-ta WANG
3, Lei TANG
2, authorsList=Gao-feng ZHU, Rui CHEN, Yi-ming ZHANG, Kai-hong ZHU, Jian-ta WANG, Lei TANG, authorCompany=null, correspAuthors=Lei TANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322906772918379071, articleId=1322906772440228413, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=黄连素衍生物WZX20在大鼠体内的药动学研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 考察黄连素衍生物WZX20在大鼠体内的药动学特征。
方法： 将SD大鼠分别灌胃和尾静脉注射WZX20，采集不同时间点血样，LC-MS测定WZX20浓度，用DAS 2.0软件进行药动学分析。
结果： WZX20灌胃药动学参数：AUC0→t为（596.46±22.22）ng·h·mL-1，AUC0-∞为（607.59±23.51）ng·h·mL-1，t1/2为（1.76±0.15）h，CL为（32.96±1.3）L·h·kg-1，Vd为（83.62±7.54）L·kg-1，Cmax为（172.98±13.51）ng·mL-1，Tmax为0.5 h，F为33.19%；WZX20静脉注射药动学参数：AUC0→t为（177.61±30.52）ng·h·mL-1，AUC0→∞为（183.08±30.90）ng·h·mL-1，t1/2为（1.74±0.17）h，CL为（11.23±2.18）L·h·kg-1，Vd为（25.17±6.81）L·kg-1。
结论： 本实验建立的检测方法专属性强、灵敏度高、准确度好，适用于WZX20血药浓度的测定。WZX20在大鼠体内的药-时曲线特征符合血管外给药一级吸收二室模型。WZX20的药动学参数为其成药性评价研究奠定了基础。
, authors=朱高峰
1, 2, 陈瑞
2, 张倚鸣
3, 朱开红
3, 王建塔
3, 汤磊
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1School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China
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1贵州医科大学基础医学院，贵阳 550025
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