Article(id=1322901727531381277, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322901641049015115, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1613577600000, acceptedDateStr=2021-02-18, onlineDate=1793333950169, onlineDateStr=2026-10-30, pubDate=1626278400000, pubDateStr=2021-07-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793333950169, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793333950169, creator=13701087609, updateTime=1793333950169, updator=13701087609, issue=Issue{id=1322901641049015115, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='13', pageStart='1153', pageEnd='1248', issueExtLink='null', onlineDate='null', pubDate='1626278400000', pubDateStr='2021-07-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793333929460, creator='13701087609', updateTime=1793333989426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322901892623376986, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322901641049015115, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322901892627571291, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322901641049015115, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1213, endPage=1219, ext={EN=ArticleExt(id=1322901729582395935, articleId=1322901727531381277, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress of calamus and prediction analysis of quality markers, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Acorus calamus was first published in “Shen Nong's Materia Medica”. It is a traditional Chinese medicine for resuscitation and is widely used in prescriptions for the treatment of closed syndrome. In view of the exact clinical efficacy of calamus and the continuous discovery of new pharmacological activities and effective ingredients, in recent years, it has attracted wide attention in China and abroad and has become one of the hot research Chinese medicine varieties. However, the current edition of “Chinese Pharmacopoeia” stipulates the traditional physical and chemical identification of calamus and the determination of the total content of volatile oil. It is still difficult to reflect and directly relate the characteristics of calamus's multiple clinical functions with multiple complex components. The current quality markers of traditional Chinese medicine have pointed out the development direction and research ideas for the establishment of quality standards in line with the characteristics of traditional Chinese medicine. This article summarizes and analyzes the chemical components and pharmacological effects of calamus by consulting literature, and based on the definition of quality markers: The “five elements” of validity, uniqueness, transmission and traceability, measurability and prescription compatibility are used to predict and analyze the quality markers of calamus. The literature review found that the volatile components of Acorus calamus, especially the asarone components, can be used as the quality markers of this drug, providing a scientific basis for its complete quality control.

, authors=He-nian YANG, Su-hui WU, Han-bing LI, Gen-lin LI, authorsList=He-nian YANG, Su-hui WU, Han-bing LI, Gen-lin LI, authorCompany=null, correspAuthors=Su-hui WU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322901729922134560, articleId=1322901727531381277, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=石菖蒲的研究进展及质量标志物预测分析, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

石菖蒲始载于《神农本草经》，为开窍药类中药，被广泛应用于治疗闭证神昏类的方剂中。鉴于石菖蒲的确切临床疗效以及新的药理活性和有效成分的不断发现，近年来被国内外广泛关注，成为热点研究的中药品种之一。然而，《中华人民共和国药典》2020年版对石菖蒲的传统理化鉴别、挥发油总含量测定等做出规定，尚难以体现和直接关联石菖蒲的多重临床疗效和多重复杂成分的特点。当前中药质量标志物（Q-marker）的提出为符合中药特色的质量标准建立指明了发展方向与研究思路，本文通过查阅文献对石菖蒲的化学成分、药理作用进行总结分析，并根据Q-marker的定义：从基于有效、特有、传递与溯源、可测和处方配伍的“五要素”对石菖蒲的Q-marker进行预测分析。文献综述结果发现，石菖蒲的挥发性成分尤以细辛醚类成分为代表可作为石菖蒲的Q-marker，为其完整的质量控制提供科学依据。

, authors=杨鹤年, 吴宿慧, 李寒冰, 李根林, authorsList=杨鹤年, 吴宿慧, 李寒冰, 李根林, authorCompany=null, correspAuthors=吴宿慧, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=hy+9l1UApmjbXcuGT5ukJw==, magXml=QKa4wkDTYW8825ZrODpcIg==, pdfUrl=null, pdf=nVWZBtSU5/sBexuUtw0ApQ==, pdfFileSize=1395925, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=h5AJ92flBOlo/XnIdPierA==, mapNumber=null, fund=null)}, authors=[Author(id=1322901730505142822, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901727531381277, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=2818558073@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322901730576445992, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901727531381277, authorId=1322901730505142822, language=EN, stringName=He-nian YANG, firstName=He-nian, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Henan University of Chinese Medicine, Henan Zhongjing Medicine Health-Aging Engineering Research Center, Zhengzhou 450046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322901730807132713, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901727531381277, authorId=1322901730505142822, language=CN, stringName=杨鹤年, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=河南中医药大学，河南省仲景方药健康衰老产业工程研究中心，郑州　450046, bio={"content":"

杨鹤年，男，硕士研究生，研究方向：中药药理学技术。E-mail：2818558073@qq.com。

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杨鹤年，男，硕士研究生，研究方向：中药药理学技术。E-mail：2818558073@qq.com。

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