Article(id=1322901686351691776, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322901641049015115, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1611072000000, acceptedDateStr=2021-01-20, onlineDate=1793333940351, onlineDateStr=2026-10-30, pubDate=1626278400000, pubDateStr=2021-07-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793333940351, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793333940351, creator=13701087609, updateTime=1793333940351, updator=13701087609, issue=Issue{id=1322901641049015115, tenantId=1146029695717560320, journalId=1235980733773295621, year='2021', volume='30', issue='13', pageStart='1153', pageEnd='1248', issueExtLink='null', onlineDate='null', pubDate='1626278400000', pubDateStr='2021-07-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793333929460, creator='13701087609', updateTime=1793333989426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322901892623376986, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322901641049015115, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322901892627571291, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1322901641049015115, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1220, endPage=1226, ext={EN=ArticleExt(id=1322901686532046849, articleId=1322901686351691776, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Preparation of indocyanine green and doxorubicin micelles and evaluation of its anti-tumor effect
in vitro, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To combine the chemotherapy and photodynamic therapy in one system, the micelles (ID-M) that co-loaded the photosensitizer indocyanine green (ICG) and the chemotherapeutic drug doxorubicin (DOX) were prepared and characterized. The anti-tumor effects of ID-M in vitro were further investigated.
Methods: An ultrasound dialysis method was used to prepare the micelles containing ICG and DOX (ID-M), while the single-encapsulated ICG micelles (I-M) and the single-encapsulated DOX micelles (D-M) were prepared using the same method as the controls. The particle size, Zeta potential, encapsulation efficiency and drug release behaviors of the micelles were measured. In addition, the anti-tumor effects and mechanism of ID-M in 4T1 cells were investigated.
Results: The average hydrated diameter of ID-M particles was 80.4 nm with negative charge, and the coefficient of the particle size dispersion was 0.252 (<0.3). The encapsulation efficiency of ICG and DOX in ID-M were 92.5% and 96.8%, respectively. The results of the temperature warming testing under irradiation of ID-M solution reached (36.5±1.1) ℃. The release experiment of ID-M in vitro showed a significant sustained-release effect. Cell experiment proved that the uptake of 4T1 cells for ID-M was nearly 2 times higher than that for free drugs. The IC50 of ID-M inhibiting the growth of 4T1 cells with irradiation was 0.72 μg·mL-1, which was 3.6-fold lower than that of free ICG/DOX. Before light exposure, ID-M was mainly located in the lysosome. However, after light exposure, the ROS levels in the cells were increased due to the existence of ICG in ID-M, which damaged the lysosomal membrane and made DOX in ID-M enter to the nucleus to play a chemotherapeutic effect.
Conclusion: In this study, the micelles (ID-M) with synergistic antitumor effects of phototherapy and chemotherapy were successfully prepared.
, authors=Mi-ya ZHANG, Liang CHEN, Hai-yan PANG, Hong YANG, authorsList=Mi-ya ZHANG, Liang CHEN, Hai-yan PANG, Hong YANG, authorCompany=null, correspAuthors=Hong YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322901687228301314, articleId=1322901686351691776, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=包载吲哚菁绿和阿霉素胶束的制备与体外抗肿瘤效果评价, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 本研究旨在联合光治疗和化疗作用，制备共包载吲哚菁绿（ICG）和阿霉素（DOX）的胶束（ID-M），对制备得到的胶束进行表征并在细胞水平考察其体外抗肿瘤效果。
方法： 采用超声透析法制备ID-M，制备单包载ICG的胶束（I-M）和单包载DOX的胶束（D-M）作为对照。对胶束的粒径、Zeta电位、包封率及释放行为等进行测定，并通过ID-M对4T1细胞的作用，考察其抗肿瘤效果和作用机制。
结果： 制得的ID-M平均水合粒径为80.4 nm且带负电，多分散系数为0.252（<0.3），ICG和DOX的包封率分别为92.5%和96.8%；ID-M的升温实验结果达到（36.5±1.1）℃。体外释放实验表明ID-M具有明显的缓释效果。细胞实验证明：4T1细胞对ID-M的摄取量较游离药物均提升了近2倍量。ID-M在光照后抑制4T1细胞生长的IC50为0.72 μg·mL-1，较游离ICG/DOX下降了3.6倍。光照前ID-M中的DOX主要定位在溶酶体中，光照后ID-M中的ICG使细胞内的ROS水平提高，溶酶体膜破坏，DOX进入细胞核中发挥化疗作用。
结论： 本研究成功制备了ID-M，有效结合光治疗和化疗发挥协同抗肿瘤作用。
, authors=张米娅, 陈亮, 庞海燕, 杨红, authorsList=张米娅, 陈亮, 庞海燕, 杨红, authorCompany=null, correspAuthors=杨红, authorNote=
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张米娅，女，硕士研究生，研究方向：肿瘤靶向纳米药物。E-mail：zmy0625@outlook.com。
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language=CN, orderNo=5, keyword=协同抗肿瘤作用)], refs=[Reference(id=1322901695700795430, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901686351691776, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=null, journalName=null, refType=null, unstructuredReference=SIEGEL RL, MILLER KD, JEMAL A. Cancer statistics, 2020[J].
CA Cancer J Clin, 2020, 70(1): 7-30., articleTitle=null, refAbstract=null), Reference(id=1322901696023756839, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901686351691776, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=null, journalName=null, refType=null, unstructuredReference=陈曦, 雷涛, 余海峰, 等. 伊布替尼单药治疗套细胞淋巴瘤的疗效与不良反应分析[J]. 中国新药与临床杂志, 2020(8): 472-477., articleTitle=null, refAbstract=null), Reference(id=1322901696099254312, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901686351691776, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=null, journalName=null, refType=null, unstructuredReference=彭颖, 唐颖楠, 周莉莉, 等. 脂质体的抗肿瘤靶向性研究进展[J]. 中国新药杂志, 2018, 27(13): 1510-1514., articleTitle=null, refAbstract=null), Reference(id=1322901696371884073, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901686351691776, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU J, LI J, LIU T. Fabrication of mixed polymeric micelles based on stimuli-responsive amphiphilic copolymers for drug delivery and controlled release[J].
Nano, 2020, 15(3): 2050040., articleTitle=null, refAbstract=null), Reference(id=1322901696443187242, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901686351691776, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=null, journalName=null, refType=null, unstructuredReference=YAN M, CAI A, LI J,
et al. Preparation of β-CD-DPPE-Dox Nanomedicine and Its' Application as the Anticancer and Antitumor Drug[J].
Scientific Reports, 2019, 9: 13670., articleTitle=null, refAbstract=null), Reference(id=1322901696510296107, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901686351691776, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=null, journalName=null, refType=null, unstructuredReference=SHI J, KANTOFF PW, WOOSTER R,
et al. Cancer nanomedicine: progress, challenges and opportunities[J].
Nat Rev Cancer, 2017, 17: 20-37., articleTitle=null, refAbstract=null), Reference(id=1322901698146074668, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901686351691776, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=null, journalName=null, refType=null, unstructuredReference=高乾乾, 张娜娜, 王昊冉, 等. 白蛋白-生育酚纳米粒的构建及其联合化疗-光疗抗乳腺癌细胞多药耐药[J]. 江苏大学学报(医学版), 2020, 30(3): 192-197., articleTitle=null, refAbstract=null), Reference(id=1322901698234155054, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901686351691776, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=null, journalName=null, refType=null, unstructuredReference=宫宇, 周春娜, 许琛. 还原响应型阿霉素前药胶束的制备及其抑制肺癌A549和乳腺癌MCF-7细胞增殖研究[J]. 中国新药杂志, 2018, 27(23): 2825-2832., articleTitle=null, refAbstract=null), Reference(id=1322901698309652527, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901686351691776, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=null, journalName=null, refType=null, unstructuredReference=LÜBTOW MM, LORSON T, FINGER T,
et al. Combining ultra-high drug-loaded micelles and injectable hydrogel drug depots for prolonged drug release[J].
Macromol Chem Phys, 2020, 221: 1900341., articleTitle=null, refAbstract=null), Reference(id=1322901698372567088, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1322901686351691776, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=null, journalName=null, refType=null, unstructuredReference=LIU Y, FLYNN TJ, FERGUSON MS,
et al. Use of the Combination Index to determine interactions between plant-derived phenolic acids on hepatotoxicity endpoints in human and rat hepatoma cells[J].
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